INT290205

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.70
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
retina 2
AAVS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 3 29.48 Quite Low
Bile 7 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leber Hereditary Optic Atrophy 6 90.12 High High
Infection 9 89.92 High High
Ganglion Cysts 8 86.92 High High
Cytomegalovirus Infection 13 82.96 Quite High
Coagulation Disorder 5 71.32 Quite High
Targeted Disruption 15 69.44 Quite High
Hyperlipidemia 19 50.00 Quite Low
Disease 11 49.20 Quite Low
Toxicity 5 34.68 Quite Low
Hyperlipoproteinemia Type Ii 66 29.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Newer AAV vectors such as the scAAV that contains complementary strands for delivery [20-22] or other AAVs with mutations in the capsid proteins designed to reduce cellular AAV degradation [23,24] that may provide the promise of higher levels of efficiency of transgene expression have not been tested in the primate retina until now.
Negative_regulation (reduce) of Protein_catabolism (degradation) of AAV in retina
1) Confidence 0.20 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2793898 Disease Relevance 0.26 Pain Relevance 0
Strategies such as blocking endosomal degradation of AAV with proteasome inhibitors significantly improve AAV transduction in mice [148,149].
Negative_regulation (blocking) of Protein_catabolism (degradation) of AAV
2) Confidence 0.12 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.44 Pain Relevance 0

General Comments

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