INT290207

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.69
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
retina 1
AAVS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 3 28.84 Quite Low
Bile 7 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leber Hereditary Optic Atrophy 6 89.48 High High
Infection 9 89.16 High High
Ganglion Cysts 8 86.28 High High
Cytomegalovirus Infection 13 82.32 Quite High
Coagulation Disorder 5 70.56 Quite High
Targeted Disruption 15 68.68 Quite High
Hyperlipidemia 19 50.00 Quite Low
Disease 11 48.44 Quite Low
Toxicity 5 33.92 Quite Low
Hyperlipoproteinemia Type Ii 66 28.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Newer AAV vectors such as the scAAV that contains complementary strands for delivery [20-22] or other AAVs with mutations in the capsid proteins designed to reduce cellular AAV degradation [23,24] that may provide the promise of higher levels of efficiency of transgene expression have not been tested in the primate retina until now.
Protein_catabolism (degradation) of AAV in retina
1) Confidence 0.35 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2793898 Disease Relevance 0.26 Pain Relevance 0
Strategies such as blocking endosomal degradation of AAV with proteasome inhibitors significantly improve AAV transduction in mice [148,149].
Protein_catabolism (degradation) of AAV
2) Confidence 0.21 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.43 Pain Relevance 0

General Comments

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