INT290265

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 5.93
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (FAT1) plasma membrane (FAT1) nucleus (FAT1)
cell-cell signaling (FAT1) cytoplasm (FAT1)
Anatomy Link Frequency
fat 8
myoblast 1
skeletal muscle 1
body 1
FAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 36 98.72 Very High Very High Very High
anesthesia 78 94.32 High High
agonist 67 91.04 High High
Inflammatory response 5 81.76 Quite High
cytokine 6 74.72 Quite High
Inflammation 5 74.32 Quite High
Versed 4 60.32 Quite High
antagonist 5 58.60 Quite High
Catecholamine 57 24.16 Low Low
cva 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 150 99.80 Very High Very High Very High
Body Weight 33 99.72 Very High Very High Very High
Impaired Glucose Tolerance 49 99.04 Very High Very High Very High
Insulin Resistance 49 98.58 Very High Very High Very High
Disease 31 98.52 Very High Very High Very High
Overweight 56 96.92 Very High Very High Very High
Appetite Loss 28 96.36 Very High Very High Very High
Injury 19 95.12 Very High Very High Very High
Diabetes Mellitus 139 92.56 High High
Hypertension 1 85.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thiopental and fentanyl could not inhibit the increases in HF and LF/HF at tracheal intubation [55].
Positive_regulation (increases) of HF at
1) Confidence 0.67 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946031 Disease Relevance 0.07 Pain Relevance 0.15
Importantly, myoblast-specific differences in DH sites at documented genes were seen most prominently within the large FAT1 gene (Figure 5 and data not shown), which is subject to complicated alternative splicing and implicated in modulating cell contacts (40) and repair of vascular smooth muscle injury (41).
Positive_regulation (subject) of FAT1 in myoblast associated with injury
2) Confidence 0.43 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.29 Pain Relevance 0
The CP cohort gained strength, but only had a slight increase in lean mass, body fat % and body weight.
Positive_regulation (increase) of fat in fat associated with body weight
3) Confidence 0.10 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3016253 Disease Relevance 0.33 Pain Relevance 0
A possible mechanism for this finding was described in an animal study by Matsuo et al. (2007), who found that a palatinose-based liquid formula suppressed postprandial glucose level and reduced visceral fat accumulation compared to a standard formula [20].
Positive_regulation (accumulation) of fat in fat
4) Confidence 0.10 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3016253 Disease Relevance 0.13 Pain Relevance 0.07
and increased glucose transporter 4 (Glut4), muscle carnitine palmitoyl-transferase (Cat), stearoyl CoA desaturase (SCoA), and fatty acid translocase (Fat) in adipose tissue, while only Fat was slightly augmented in the liver which expresses very little hepatic PPAR?.
Positive_regulation (augmented) of Fat in Fat associated with obesity
5) Confidence 0.10 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.43 Pain Relevance 0.17
In summary, there is evidence to suggest that regular HIIE results in increased fat oxidation during exercise; however, the effects of HIIE on postexercise fat oxidation and appetite suppression have not been examined.

4.

Positive_regulation (increased) of fat in fat associated with appetite loss
6) Confidence 0.07 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.57 Pain Relevance 0.03
and increased glucose transporter 4 (Glut4), muscle carnitine palmitoyl-transferase (Cat), stearoyl CoA desaturase (SCoA), and fatty acid translocase (Fat) in adipose tissue, while only Fat was slightly augmented in the liver which expresses very little hepatic PPAR?.
Positive_regulation (increased) of Fat in Fat associated with obesity
7) Confidence 0.07 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.37 Pain Relevance 0.17
Our study showed that an increase in fat mass might not in isolation be a major contributor to elevated S100B levels.
Positive_regulation (increase) of fat in fat
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 1.19 Pain Relevance 0.04
HIIE also significantly lowers insulin resistance and results in a number of skeletal muscle adaptations that result in enhanced skeletal muscle fat oxidation and improved glucose tolerance.
Positive_regulation (enhanced) of fat in skeletal muscle associated with tolerance, insulin resistance and impaired glucose tolerance
9) Confidence 0.05 Published 2011 Journal Journal of Obesity Section Abstract Doc Link PMC2991639 Disease Relevance 0.29 Pain Relevance 0.05
The mechanisms underlying the fat reduction induced by HIIE, however, are undetermined but may include HIIE-induced fat oxidation during and after exercise and suppressed appetite.
Positive_regulation (induced) of fat in fat
10) Confidence 0.05 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.49 Pain Relevance 0
Possible mechanisms underlying the HIIE-induced fat loss effect include increased exercise and postexercise fat oxidation and decreased postexercise appetite.
Positive_regulation (induced) of fat in fat
11) Confidence 0.05 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.61 Pain Relevance 0
However, others have suggested that the prevalence of glucose intolerance in older individuals is not a direct reflection of one's lean body mass, but a result of age-associated increases in abdominal fat [32–34].
Neg (not) Positive_regulation (increases) of fat in body associated with impaired glucose tolerance
12) Confidence 0.04 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 1.15 Pain Relevance 0.24

General Comments

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