INT290267

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Context Info
Confidence 0.71
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.63
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (FRG1) nucleus (FRG1)
Anatomy Link Frequency
myoblasts 2
muscle 2
FRG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Facioscapulohumeral Muscular Dystrophy 450 99.68 Very High Very High Very High
Sprains And Strains 114 89.84 High High
Disease 126 67.76 Quite High
Hepatocellular Cancer 12 63.52 Quite High
Myeloid Leukemia 12 61.40 Quite High
Hypersensitivity 6 50.00 Quite Low
Frailty 6 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Shock 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only one of these, FRG1, is expressed at a substantial level in myoblasts or other tested cell types (Table 1).
Gene_expression (expressed) of FRG1 in myoblasts
1) Confidence 0.71 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.27 Pain Relevance 0
Only two of these, namely, DHFRG1 (in the promoter of FRG1) and DH272 (in the distal gene desert) did not overlap a DNA repeat.
Gene_expression (two) of FRG1
2) Confidence 0.65 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.17 Pain Relevance 0
Only two of these, namely, DHFRG1 (in the promoter of FRG1) and DH272 (in the distal gene desert) did not overlap a DNA repeat.
Gene_expression (two) of FRG1
3) Confidence 0.62 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.17 Pain Relevance 0
With respect to DHFRG1, the DH site at the FRG1 promoter, one group reported overexpression of FRG1 RNA in FSHD muscle (17) but several others were unable to confirm this (11–13).
Gene_expression (overexpression) of FRG1 in muscle associated with facioscapulohumeral muscular dystrophy
4) Confidence 0.62 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.38 Pain Relevance 0
Among the FSHD candidate genes on 4q35, DH sites were detected only at the promoters of FRG1 and SLC25A and no significant differences in DH peak intensity were observed between FSHD and control myoblasts (Figure 4, inset and data not shown).
Gene_expression (detected) of FRG1 in myoblasts associated with facioscapulohumeral muscular dystrophy
5) Confidence 0.62 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.88 Pain Relevance 0
Overexpression of FRG2, FRG1 and SLC25A4 RNA in FSHD versus control muscle was reported to be >60-, >25- and ?
Gene_expression (Overexpression) of FRG1 in muscle associated with facioscapulohumeral muscular dystrophy
6) Confidence 0.55 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.76 Pain Relevance 0

General Comments

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