INT290313

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (MYD88, TLR7) plasma membrane (MYD88, TLR7) intracellular (MYD88, TLR7)
cytoplasm (MYD88, TLR7) endosome (TLR7) cytosol (MYD88)
MYD88 (Homo sapiens)
TLR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 54.80 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 67 99.16 Very High Very High Very High
Viral Infection 1 47.28 Quite Low
Aging 2 35.04 Quite Low
Infection 4 34.56 Quite Low
Frailty 1 24.12 Low Low
Sprains And Strains 38 5.00 Very Low Very Low Very Low
Critical Illness 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Pneumonia 4 5.00 Very Low Very Low Very Low
Immunization 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Once TLR7 recognizes ssRNA, the adaptor protein myeloid differentiation primary response protein 88 (MyD88), via down-stream signal activation of transcription factors, results in the production of type I Interferons (IFNs) and inhibition of viral replication.
MyD88 Binding (recognizes) of TLR7
1) Confidence 0.03 Published 2009 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2794489 Disease Relevance 0.10 Pain Relevance 0.03

General Comments

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