INT290336

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Context Info
Confidence 0.31
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.77
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Scarb1) plasma membrane (Scarb1) cytoplasm (Scarb1)
Anatomy Link Frequency
14.2 1
Scarb1 (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 6 91.80 High High
Inflammation 29 78.76 Quite High
cytokine 12 69.16 Quite High
imagery 3 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 153 99.84 Very High Very High Very High
Disorder Of Lipid Metabolism 33 99.44 Very High Very High Very High
Atherosclerosis 21 99.26 Very High Very High Very High
Infection 61 87.32 High High
Disease 15 83.16 Quite High
INFLAMMATION 27 78.76 Quite High
Granuloma 6 68.28 Quite High
Sprains And Strains 9 41.88 Quite Low
Hyperlipoproteinemia Type Ii 47 24.76 Low Low
Cardiovascular Disease 37 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like many other receptors for these pathogens, the loss of SR-B1 can be functionally compensated for under normal conditions.



Negative_regulation (loss) of SR-B1
1) Confidence 0.31 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2794535 Disease Relevance 0.68 Pain Relevance 0.07
C57BL/6 mice deficient in SR-B1 and its splice variant SR-B2 (Scarb1tm1Kri/Scarb1tm1Kri) were purchased from the Jackson Laboratory which were originally derived by Rigotti et al. [50].
Negative_regulation (deficient) of SR-B1
2) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794535 Disease Relevance 0 Pain Relevance 0.09
On the one hand, this redundancy of SR-B1 in mycobacterial infection might be a result, at least in part, of surfactant blocking the bacterial-receptor interactions, as we demonstrated in vitro (Fig. 2D).
Negative_regulation (redundancy) of SR-B1 associated with mycobacterial infection
3) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794535 Disease Relevance 0.68 Pain Relevance 0
The possible adverse effects of ezetimibe were explained on the basis of mild inhibition of acyl coenzyme A: cholesterol acyltransferase, which may worsen atherosclerosis.87 Ezetimibe has also been shown to inhibit SRB1, the hepatic HDL receptor, a mechanism that may inhibit reverse cholesterol transport and promote atherogenesis.87 Recently, ezetimibe was shown to increase the proportion of small, dense LDL-particles (sdLDL) in normal subjects after 2 weeks of therapy.89 Ezetimibe significantly increased the sdLDL subfractions LDL-IVA and LDL-IVB (+14.2% and +16.7%, respectively), whereas simvastatin significantly decreased the LDL-IVB subfraction (?
Negative_regulation (inhibit) of SRB1 in 14.2 associated with atherosclerosis and disorder of lipid metabolism
4) Confidence 0.24 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.40 Pain Relevance 0

General Comments

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