INT29035

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Context Info
Confidence 0.41
First Reported 1987
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.47
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Wnt1) extracellular space (Wnt1) extracellular region (Wnt1)
proteinaceous extracellular matrix (Wnt1) plasma membrane (Wnt1) cell-cell signaling (Wnt1)
Wnt1 (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 13 100.00 Very High Very High Very High
narcan 9 99.78 Very High Very High Very High
tail-flick 5 99.56 Very High Very High Very High
antagonist 1 93.84 High High
tolerance 3 93.52 High High
Morphine 1 87.76 High High
Antinociceptive 2 82.76 Quite High
Endogenous opioid 2 79.44 Quite High
Dopamine 8 72.80 Quite High
Locus ceruleus 2 59.36 Quite High
Disease Link Frequency Relevance Heat
Lung Cancer 136 99.60 Very High Very High Very High
Apoptosis 23 99.48 Very High Very High Very High
Stress 6 94.88 High High
Malignant Neoplastic Disease 11 90.48 High High
Cancer 56 57.20 Quite High
Metastasis 9 49.28 Quite Low
Disease 11 39.00 Quite Low
Adhesions 8 5.84 Low Low
Solid Tumor 5 5.00 Very Low Very Low Very Low
Mental Disorders 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous studies have shown that the flanked Lmx1b allele was deleted in Wnt1-Cre; Lmx1bflox/?
Negative_regulation (deleted) of Wnt1
1) Confidence 0.41 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.18
On the other hand, FS-SIA was antagonized by naloxone in both methods, while naloxone failed to reverse SW-SIA in either TF or TP assessment.
Neg (failed) Negative_regulation (reverse) of SW-SIA associated with tail-flick, narcan and analgesia
2) Confidence 0.03 Published 1987 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2821308 Disease Relevance 0.42 Pain Relevance 1.83
Recent work has shown that Wnt-1, member of the Wnt family, is involved in inhibition of apoptosis in MM in vitro, and that inhibition of Wnt-1 or its receptor Dishevelled induces apoptosis via JNK activation (You, 2004).
Negative_regulation (inhibition) of Wnt-1 associated with lung cancer and apoptosis
3) Confidence 0.01 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.05 Pain Relevance 0

General Comments

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