INT290377

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Context Info
Confidence 0.24
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.95
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (NOD2, TLR2) cytoplasm (NOD2, TLR2) cytosol (NOD2)
signal transduction (TLR2) intracellular (TLR2) enzyme binding (NOD2)
Anatomy Link Frequency
bowel 2
NOD2 (Homo sapiens)
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 1 99.58 Very High Very High Very High
Inflammation 16 96.80 Very High Very High Very High
Fibrositis 97 62.40 Quite High
Pain 9 43.36 Quite Low
spastic colon 1 18.80 Low Low
chemokine 12 9.68 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
Catechol-O-methyltransferase 4 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 12 99.58 Very High Very High Very High
INFLAMMATION 17 96.80 Very High Very High Very High
Familial Mediterranean Fever 25 92.52 High High
Syndrome 7 89.24 High High
Fever 3 84.44 Quite High
Apoptosis 1 69.00 Quite High
Fibromyalgia 97 62.40 Quite High
Death 3 55.20 Quite High
Pain 10 43.36 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 19.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This situation would be similar to the role of NOD2 in Crohn's disease, in which wild type NOD2, also a member of the NLR family [40], inhibits TLR2 (toll-like receptor-2) activation by peptidoglycan, while mutated NOD2 fails to inhibit TLR2, leading to chronic inflammation in the bowel [41].
NOD2 Negative_regulation (inhibits) of Positive_regulation (activation) of toll-like receptor-2 in bowel associated with inflammation, crohn's disease and disease
1) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.95 Pain Relevance 0.23

General Comments

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