INT290399

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Context Info
Confidence 0.59
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.59
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mef2c) nucleus (Mef2c) DNA binding (Mef2c)
protein complex (Mef2c) cytoplasm (Mef2c)
Anatomy Link Frequency
ventricle 6
Mef2c (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 60 51.80 Quite High
anesthesia 18 5.00 Very Low Very Low Very Low
ketamine 12 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 48 83.92 Quite High
Left Ventricular Hypertrophy 60 78.88 Quite High
Targeted Disruption 12 72.72 Quite High
Coronary Heart Disease 78 64.48 Quite High
Adhesions 6 58.00 Quite High
Fibrosis 60 51.80 Quite High
Congenital Anomalies 12 46.48 Quite Low
Hypertrophy 54 42.88 Quite Low
Myocardial Infarction 18 34.40 Quite Low
Heart Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 3A, MEF2C protein expression was reduced by approximately 75% in the left ventricle of control mice up to the 4th day after the administration of siMEF2C.
Negative_regulation (reduced) of Gene_expression (expression) of MEF2C in ventricle
1) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
The expression of MEF2C was reduced in cardiomyocytes harvested from the left ventricle 24 hours after the treatment with siMEF2C to similar levels of myocardial extracts (?
Negative_regulation (reduced) of Gene_expression (expression) of MEF2C in ventricle
2) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
Accordingly, we have shown here that MEF2C depletion markedly attenuated the rise of PGC-1?
Negative_regulation (attenuated) of Gene_expression (depletion) of MEF2C
3) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.28 Pain Relevance 0
We started off with 450 µg/Kg of siMEF2C based on a previous report[19] and observed an expressive reduction, of about 85%, of myocardial MEF2C protein expression 1 day after bolus injections of 900 µg/Kg of siMEF2C (Figure 2A).
Negative_regulation (reduction) of Gene_expression (expression) of MEF2C
4) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
Transfection of siMEF2C (300 ng/ml) reduced the MEF2C transcripts in NRVMs by approximately 80% (Figure 1A). siMEF2C had no influence in the amounts of MEF2A, MEF2B or MEF2D transcripts (Figure 1B-D).
Negative_regulation (reduced) of Gene_expression (Transfection) of siMEF2C
5) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.25 Pain Relevance 0.03
As shown in Figure 3A, MEF2C protein expression was reduced by approximately 75% in the left ventricle of control mice up to the 4th day after the administration of siMEF2C.
Negative_regulation (reduced) of Gene_expression (expression) of siMEF2C in ventricle
6) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.06 Pain Relevance 0

General Comments

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