INT290407

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.93
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mef2c) nucleus (Mef2c) DNA binding (Mef2c)
protein complex (Mef2c) cytoplasm (Mef2c)
Anatomy Link Frequency
ventricle 2
cardiomyocytes 2
Mef2c (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 20 78.44 Quite High
anesthesia 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 26 96.60 Very High Very High Very High
Stress 16 86.44 High High
Hypertrophy 18 80.00 Quite High
Fibrosis 20 78.44 Quite High
Myocardial Infarction 6 74.28 Quite High
Injury 2 63.60 Quite High
Heart Disease 4 60.76 Quite High
Left Ventricular Hypertrophy 20 50.00 Quite Low
Targeted Disruption 4 46.32 Quite Low
Adhesions 2 28.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of MEF2C was reduced in cardiomyocytes harvested from the left ventricle 24 hours after the treatment with siMEF2C to similar levels of myocardial extracts (?
Positive_regulation (with) of siMEF2C Binding (treatment) of in ventricle
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
In this context, many studies have shown that overall MEF2 DNA-binding activity is enhanced in cardiomyocytes in response to biomechanical and neurohormonal stimuli[11], [12], [13].
Positive_regulation (enhanced) of MEF2 Binding (binding) of in cardiomyocytes
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.93 Pain Relevance 0.04

General Comments

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