INT290411

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Context Info
Confidence 0.65
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 3.72
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Ptk2b) nucleus (Ptk2b) kinase activity (Ptk2b)
cytoplasm (Ptk2b)
Anatomy Link Frequency
hippocampus 6
neurons 1
Ptk2b (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 216 99.42 Very High Very High Very High
nMDA receptor 54 87.64 High High
chemokine 102 76.20 Quite High
Glutamate 1053 70.48 Quite High
Pyramidal cell 9 62.64 Quite High
Neurotransmitter 54 50.00 Quite Low
Central nervous system 63 5.00 Very Low Very Low Very Low
Inflammation 36 5.00 Very Low Very Low Very Low
Inflammatory response 27 5.00 Very Low Very Low Very Low
anesthesia 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 108 100.00 Very High Very High Very High
Targeted Disruption 704 97.80 Very High Very High Very High
Wiskott-aldrich Syndrome 9 65.64 Quite High
Carcinoma 25 65.12 Quite High
Breast Cancer 4 64.68 Quite High
Bordatella Infection 3 57.20 Quite High
Colon Cancer 25 50.00 Quite Low
Left Ventricular Hypertrophy 10 50.00 Quite Low
Hypertrophy 9 48.40 Quite Low
Apoptosis 100 10.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, the immunohistochemical characterization of PTK2B and phospho-PTK2B levels in hippocampal neurons indicated that not only protein levels but also biochemical activation (i.e., phosphorylation) of PTK2B were significantly increased in the Tg mouse hippocampus.
Gene_expression (levels) of PTK2B in hippocampus associated with targeted disruption and hippocampus
1) Confidence 0.65 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.45 Pain Relevance 0.05
Overall, the immunohistochemical characterization of PTK2B and phospho-PTK2B levels in hippocampal neurons indicated that not only protein levels but also biochemical activation (i.e., phosphorylation) of PTK2B were significantly increased in the Tg mouse hippocampus.
Gene_expression (levels) of PTK2B in hippocampus associated with targeted disruption and hippocampus
2) Confidence 0.65 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.40 Pain Relevance 0.05
Immunohistochemical analysis of PTK2B and PTK2BpY402 levels
Gene_expression (analysis) of PTK2B
3) Confidence 0.65 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.35 Pain Relevance 0
Immunohistochemical characterization of PTK2B and phospho-PTK2B levels in hippocampal neurons
Gene_expression (levels) of PTK2B in neurons
4) Confidence 0.65 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.07 Pain Relevance 0.15
Yet, despite the loss of labelling by MAP2A, PTK2B labelling appeared to be well preserved in the dendrites of neurons from the Glud1 mice as revealed by the lack of significant differences in the same fields of the stratum radiatum of the CA1 region from the same sections of Glud1 and wt mouse hippocampus as those analyzed for MAP2A labelling (PTK2B = 43.72 ± 4.21, for Glud1; 41.32 ± .03, for wt; n = 3 Tg and 3 wt mice; P = 0.69, ANOVA).
Gene_expression (labelling) of PTK2B in hippocampus associated with targeted disruption and hippocampus
5) Confidence 0.65 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.18 Pain Relevance 0.19
Immunohistochemical analysis of PTK2B and PTK2BpY402 levels
Gene_expression (analysis) of PTK2BpY402
6) Confidence 0.65 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.36 Pain Relevance 0
In addition to the PTK2B labelling in dendrites, the levels of the phosphorylated form of PTK2B, PTK2BpY402, were also well preserved in the CA1 region of the hippocampus from Glud1 mice (Figure 3D, H).
Gene_expression (levels) of PTK2BpY402 in hippocampus associated with hippocampus
7) Confidence 0.58 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.31 Pain Relevance 0.16
Yet, despite the loss of labelling by MAP2A, PTK2B labelling appeared to be well preserved in the dendrites of neurons from the Glud1 mice as revealed by the lack of significant differences in the same fields of the stratum radiatum of the CA1 region from the same sections of Glud1 and wt mouse hippocampus as those analyzed for MAP2A labelling (PTK2B = 43.72 ± 4.21, for Glud1; 41.32 ± .03, for wt; n = 3 Tg and 3 wt mice; P = 0.69, ANOVA).
Spec (analyzed) Gene_expression (labelling) of PTK2B in hippocampus associated with targeted disruption and hippocampus
8) Confidence 0.57 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.24 Pain Relevance 0.19
As shown in Figure 3C, no change was detected in the myocardial levels of FAK (Focal Adhesion Kinase), JNK (c-Jun N-Terminal Kinase) or Shp2 (Src homology region 2, phosphatase 2) after treatment with siMEF2C.
Gene_expression (levels) of Focal Adhesion Kinase associated with adhesions
9) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.10 Pain Relevance 0
In addition to the PTK2B labelling in dendrites, the levels of the phosphorylated form of PTK2B, PTK2BpY402, were also well preserved in the CA1 region of the hippocampus from Glud1 mice (Figure 3D, H).
Gene_expression (levels) of PTK2B in hippocampus associated with hippocampus
10) Confidence 0.26 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.31 Pain Relevance 0.16
Immunoblot analysis indicated that CXCL12 re-expression decreased active and total protein levels of Pyk2, paxillin, FAK, and p130Cas (Figure 2A).
Gene_expression (levels) of Pyk2
11) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.97 Pain Relevance 0.07

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