INT290415

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Context Info
Confidence 0.17
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppargc1a) RNA binding (Ppargc1a) mitochondrion organization (Ppargc1a)
nucleus (Ppargc1a) DNA binding (Ppargc1a) transcription factor binding (Ppargc1a)
Anatomy Link Frequency
ventricle 2
Ppargc1a (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 10 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 9 96.64 Very High Very High Very High
Coronary Heart Disease 13 79.36 Quite High
Left Ventricular Hypertrophy 10 50.00 Quite Low
Tuberous Sclerosis 1 42.72 Quite Low
Fibrosis 10 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low
Myocardial Infarction 3 5.00 Very Low Very Low Very Low
Heart Disease 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, these data support the notion that depletion of MEF2C attenuates the load-induced replication of mtDNA and likely in mitochondrial biogenesis in mice left ventricle, associated to a defect in the regulation of PGC-1?
Negative_regulation (defect) of Regulation (regulation) of PGC-1 in ventricle
1) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.18 Pain Relevance 0

General Comments

This test has worked.

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