INT290417

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.25
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mef2c) nucleus (Mef2c) DNA binding (Mef2c)
protein complex (Mef2c) cytoplasm (Mef2c)
Anatomy Link Frequency
ventricle 2
cardiomyocytes 2
Mef2c (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 30 73.32 Quite High
anesthesia 9 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 27 92.32 High High
Coronary Heart Disease 39 91.48 High High
Stress 24 81.32 Quite High
Left Ventricular Hypertrophy 30 78.88 Quite High
Fibrosis 30 73.32 Quite High
Myocardial Infarction 9 69.16 Quite High
Injury 3 58.48 Quite High
Targeted Disruption 6 56.16 Quite High
Heart Disease 6 55.64 Quite High
Adhesions 3 27.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of MEF2C was reduced in cardiomyocytes harvested from the left ventricle 24 hours after the treatment with siMEF2C to similar levels of myocardial extracts (?
Positive_regulation (with) of Gene_expression (expression) of MEF2C in ventricle
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0 Pain Relevance 0
Overexpression of MEF2A or MEF2C in cultured cardiomyocytes induces sarcomere degeneration and cardiomyocytes elongation, suggesting that activation of these members may compose signaling pathways responsible for pathologic hypertrophy [8].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of MEF2C in cardiomyocytes associated with hypertrophy
2) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 1.00 Pain Relevance 0.04
Transfection of siMEF2C (300 ng/ml) reduced the MEF2C transcripts in NRVMs by approximately 80% (Figure 1A). siMEF2C had no influence in the amounts of MEF2A, MEF2B or MEF2D transcripts (Figure 1B-D).
Positive_regulation (Transfection) of Gene_expression (Transfection) of siMEF2C
3) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.25 Pain Relevance 0.03

General Comments

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