INT290443

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.56
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP2, MMP2) peptidase activity (MMP2) extracellular space (MMP2)
proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)
Anatomy Link Frequency
brain 2
TIMP2 (Homo sapiens)
MMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3 90.48 High High
palliative 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 1 99.68 Very High Very High Very High
Cancer 45 99.64 Very High Very High Very High
Disease 3 99.02 Very High Very High Very High
Breast Cancer 2 97.36 Very High Very High Very High
Metastasis 13 96.12 Very High Very High Very High
Osteogenic Sarcomas 1 94.00 High High
Skin Cancer 2 76.64 Quite High
Pancreatic Cancer 1 76.24 Quite High
Melanoma 73 74.80 Quite High
Brain Tumor 1 69.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, over-expression of TIMP2 in tumour stroma was associated with increased disease-free survival in prostate cancer [32], and down-regulation of MMP2 by TIMP2 over-expression reduced tumour growth and metastatic potential in a rat model of breast cancer-associated brain metastasis [33].
Gene_expression (expression) of TIMP2 in brain Negative_regulation (regulation) of MMP2 associated with cancer, breast cancer, disease, metastasis and reprotox - general 1
1) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.56 Pain Relevance 0.13

General Comments

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