INT29045

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Context Info
Confidence 0.05
First Reported 1982
Last Reported 2008
Negated 1
Speculated 3
Reported most in Abstract
Documents 10
Total Number 13
Disease Relevance 5.93
Pain Relevance 8.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Etf1)
Anatomy Link Frequency
dorsal root ganglia 2
prefrontal 1
DRN 1
hippocampus 1
cerebellum 1
Etf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 194 100.00 Very High Very High Very High
Dopamine 171 100.00 Very High Very High Very High
Glutamate 38 100.00 Very High Very High Very High
Endogenous opioid 1 99.84 Very High Very High Very High
dorsal root ganglion 355 99.76 Very High Very High Very High
opioid receptor 6 99.54 Very High Very High Very High
Hippocampus 9 99.28 Very High Very High Very High
Morphine 6 98.44 Very High Very High Very High
peripheral neuropathy 15 98.32 Very High Very High Very High
Sciatic nerve 75 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 360 99.76 Very High Very High Very High
Neuropathic Pain 95 99.72 Very High Very High Very High
Nerve Compression Syndromes 225 99.28 Very High Very High Very High
Injury 36 99.12 Very High Very High Very High
Peripheral Neuropathy 15 98.32 Very High Very High Very High
Pain 40 97.92 Very High Very High Very High
Diabetes Mellitus 10 97.20 Very High Very High Very High
Urological Neuroanatomy 2 81.12 Quite High
Nociception 35 62.04 Quite High
Attention Deficit Hyperactivity Disorder 30 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, to investigate whether depolarization of dopaminergic terminal was able to affect MeHg-induced DA release, we infused 75 mM KCl through the dialysis membrane.
Spec (whether) Regulation (affect) of release associated with dopamine
1) Confidence 0.05 Published 2002 Journal Neurochem. Int. Section Abstract Doc Link 11821154 Disease Relevance 0 Pain Relevance 0.79
Perfusion of [3H]NE-loaded slices with 5 mU/ml insulin did not affect S2 release.
Neg (not) Regulation (affect) of release
2) Confidence 0.03 Published 1995 Journal Pharmacology Section Abstract Doc Link 8966194 Disease Relevance 0.69 Pain Relevance 0.37
We next compared the effects of yoked IV injections of cocaine HCl or cocaine MI on ventral tegmental glutamate and dopamine release in cocaine HCl-trained or saline-trained rats.
Regulation (effects) of release in ventral associated with dopamine, glutamate and cocaine
3) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2475658 Disease Relevance 0 Pain Relevance 1.42
These results indicate that DRN is one site at which systemically-administered morphine might act, and suggest the possibility of participation of this mechanism in modulation of prolactin release by endogenous opioids.
Regulation (modulation) of release in DRN associated with endogenous opioid and morphine
4) Confidence 0.02 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 6290924 Disease Relevance 0.15 Pain Relevance 0.88
These results suggest that in the rat only mu type opioid receptors mediate an inhibitory regulation of NE release from the cortex, hippocampus and cerebellum terminal projections of locus coeruleus noradrenergic neurons.
Regulation (regulation) of release in cortex associated with locus ceruleus, hippocampus and opioid receptor
5) Confidence 0.01 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 2821438 Disease Relevance 0 Pain Relevance 0.70
To determine if altered ATP release was a consequence of altered DRG metabolism we compared O2 consumption between control and neuropathic DRG.
Regulation (altered) of release associated with neuropathic pain
6) Confidence 0.01 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2630978 Disease Relevance 0.88 Pain Relevance 0.25
We used extracellular sampling from an in vitro dorsal root ganglion (DRG) preparation [33] to assess possible changes in ATP release from DRG in a rat model of neuropathy induced by sciatic nerve entrapment [34] and examine possible mechanisms and consequences of such alterations.
Spec (possible) Regulation (changes) of release in DRG associated with ganglion cysts, dorsal root ganglion, neuropathic pain, nerve compression syndromes and sciatic nerve
7) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 1.25 Pain Relevance 1.03
Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats

Background

Regulation (Altered) of release in dorsal root ganglia associated with neuropathic pain
8) Confidence 0.01 Published 2008 Journal Mol Pain Section Title Doc Link PMC2630978 Disease Relevance 0.83 Pain Relevance 0.39
We measured nanomolar ATP levels with the luciferin-luciferase assay after bulk equilibration of perfusate samples with the DRG preparation, permitting relative comparisons of changes in basal and evoked ATP release after neuropathy induction.
Regulation (changes) of release associated with dorsal root ganglion and neuropathic pain
9) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 1.35 Pain Relevance 0.47
We investigated the changes in basal and KCl-evoked ATP release from rat dorsal root ganglia (DRG) after peripheral neuropathy induction by unilateral sciatic nerve entrapment (SNE).


Spec (investigated) Regulation (changes) of release in sciatic nerve associated with nerve compression syndromes, sciatic nerve and peripheral neuropathy
10) Confidence 0.01 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2630978 Disease Relevance 0.78 Pain Relevance 0.28
Tonic dopamine release is regulated via presynaptic N-methyl-d-aspartate (NMDA) receptors in a spike-independent manner by glutamatergic prefrontal cortical afferents.
Regulation (regulated) of release in prefrontal associated with dopamine
11) Confidence 0.00 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701285 Disease Relevance 0 Pain Relevance 0.71
These results suggest that in the rat only mu type opioid receptors mediate an inhibitory regulation of NE release from the cortex, hippocampus and cerebellum terminal projections of locus coeruleus noradrenergic neurons.
Regulation (regulation) of release in hippocampus associated with locus ceruleus, hippocampus and opioid receptor
12) Confidence 0.00 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 2821438 Disease Relevance 0 Pain Relevance 0.70
These results suggest that in the rat only mu type opioid receptors mediate an inhibitory regulation of NE release from the cortex, hippocampus and cerebellum terminal projections of locus coeruleus noradrenergic neurons.
Regulation (regulation) of release in cerebellum associated with locus ceruleus, hippocampus and opioid receptor
13) Confidence 0.00 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 2821438 Disease Relevance 0 Pain Relevance 0.70

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