INT290461

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Context Info
Confidence 0.59
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.13
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mitf) cell differentiation (Mitf) nucleus (Mitf)
protein complex assembly (Mitf) DNA binding (Mitf) protein complex (Mitf)
Mitf (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
wide dynamic range 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 1 100.00 Very High Very High Very High
Melanoma 146 99.84 Very High Very High Very High
Skin Cancer 11 99.84 Very High Very High Very High
Cancer 90 98.04 Very High Very High Very High
Stress 6 97.80 Very High Very High Very High
Disease 10 97.48 Very High Very High Very High
Hypopigmentation 1 89.36 High High
Metastasis 26 84.60 Quite High
Adhesions 6 82.24 Quite High
Aggression 4 63.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A number of mechanisms have been postulated to alter MITF expression in melanoma.
Spec (postulated) Regulation (alter) of Gene_expression (expression) of MITF associated with melanoma
1) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.20 Pain Relevance 0
We found that MITF transcript levels did not correlate with CD200, a proxy of ERK activation, which agrees with the conclusions of others that if ERK activation caused by, for example, BRAF mutation, regulates MITF expression in melanoma then it is only weakly so at the level of transcription.
Regulation (regulates) of Gene_expression (expression) of MITF associated with melanoma
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.80 Pain Relevance 0
Abnormalities in TFAP2A, KIT, and MITF expression in melanoma highlight the importance of this pathway in human disease.
Regulation (Abnormalities) of Gene_expression (expression) of MITF associated with congenital anomalies, disease and skin cancer
3) Confidence 0.17 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2940735 Disease Relevance 0.62 Pain Relevance 0
When considering the targeting genes of differentially expressed miRNAs, the genes involved in metabolic process, response to stress and vasculogenesis are significantly enriched among the differentially expressed genes in both groups.
Regulation (targeting) of Gene_expression (expressed) of miRNAs associated with stress
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0.35 Pain Relevance 0
The differentially expressed miRNAs and their coherent mRNA targets were listed in Table S4.
Regulation (targets) of Gene_expression (expressed) of miRNAs
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0.16 Pain Relevance 0

General Comments

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