INT290461

Context Info Confidence 0.59 First Reported 2009 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 3 Total Number 5 Disease Relevance 3.13 Pain Relevance 0

pigmentation (Mitf) cell differentiation (Mitf) nucleus (Mitf) protein complex assembly (Mitf) DNA binding (Mitf) protein complex (Mitf)

Mitf (Mus musculus)

Pain Link Frequency Relevance Heat metalloproteinase 8 5.00 Central nervous system 4 5.00 dexamethasone 3 5.00 palliative 2 5.00 Spinal cord 2 5.00 anesthesia 2 5.00 depression 2 5.00 wide dynamic range 2 5.00 addiction 1 5.00 melanocortin 1 receptor 1 5.00

Disease Link Frequency Relevance Heat Congenital Anomalies 1 100.00 Melanoma 146 99.84 Skin Cancer 11 99.84 Cancer 90 98.04 Stress 6 97.80 Disease 10 97.48 Hypopigmentation 1 89.36 Metastasis 26 84.60 Adhesions 6 82.24 Aggression 4 63.80

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A number of mechanisms have been postulated to alter MITF expression in melanoma.

Spec (postulated) Regulation (alter) of Gene_expression (expression) of MITF associated with melanoma

1) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.20 Pain Relevance 0

We found that MITF transcript levels did not correlate with CD200, a proxy of ERK activation, which agrees with the conclusions of others that if ERK activation caused by, for example, BRAF mutation, regulates MITF expression in melanoma then it is only weakly so at the level of transcription.

Regulation (regulates) of Gene_expression (expression) of MITF associated with melanoma

2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.80 Pain Relevance 0

Abnormalities in TFAP2A, KIT, and MITF expression in melanoma highlight the importance of this pathway in human disease.

Regulation (Abnormalities) of Gene_expression (expression) of MITF associated with congenital anomalies, disease and skin cancer

3) Confidence 0.17 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2940735 Disease Relevance 0.62 Pain Relevance 0

When considering the targeting genes of differentially expressed miRNAs, the genes involved in metabolic process, response to stress and vasculogenesis are significantly enriched among the differentially expressed genes in both groups.

Regulation (targeting) of Gene_expression (expressed) of miRNAs associated with stress

4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0.35 Pain Relevance 0

The differentially expressed miRNAs and their coherent mRNA targets were listed in Table S4.

Regulation (targets) of Gene_expression (expressed) of miRNAs

5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0.16 Pain Relevance 0

General Comments

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