INT290473

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Context Info
Confidence 0.24
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.71
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLAUR) extracellular region (PLAUR) plasma membrane (PLAUR)
enzyme binding (PLAUR)
Anatomy Link Frequency
lymph node 2
PLAUR (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3 48.20 Quite Low
depression 1 38.24 Quite Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 13 100.00 Very High Very High Very High
Hypoxia 4 99.90 Very High Very High Very High
Melanoma 73 98.76 Very High Very High Very High
Colon Cancer 1 78.80 Quite High
Brain Tumor 1 75.28 Quite High
Cancer 45 72.24 Quite High
Skin Cancer 2 72.04 Quite High
Breast Cancer 2 62.60 Quite High
Nevus 7 58.08 Quite High
Reprotox - General 1 1 57.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypoxia can promote lymph node metastasis via up-regulation of PLAUR [39], and up-regulation of HIF1a, JUN and PLAUR in our invasive cell lines hints at possible activation of JUN/AP1 and HIF/ARNT pathways in melanoma (Figure 5).
Positive_regulation (promote) of Regulation (regulation) of PLAUR in lymph node associated with melanoma, hypoxia and metastasis
1) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.71 Pain Relevance 0

General Comments

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