INT290475

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (POU3F2, Mitf) pigmentation (Mitf) cell differentiation (Mitf)
protein complex assembly (Mitf) DNA binding (Mitf) protein complex (Mitf)
POU3F2 (Homo sapiens)
Mitf (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 73 99.92 Very High Very High Very High
Cancer 45 96.64 Very High Very High Very High
Metastasis 13 83.20 Quite High
Aggression 2 62.40 Quite High
Disease 3 50.52 Quite High
Skin Cancer 2 47.64 Quite Low
Nevus 7 17.12 Low Low
Hypoxia 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BRN2 has been reported to be a negative regulator of MITF in melanoma cells [22], yet we were unable to show any correlation between MITF and BRN2 transcription in this study, with any potential correlation tending towards positive rather than negative at the transcript level.
BRN2 Negative_regulation (regulator) of MITF associated with melanoma
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.14 Pain Relevance 0

General Comments

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