INT290477

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.36
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (POU3F2, Mitf) pigmentation (Mitf) cell differentiation (Mitf)
protein complex assembly (Mitf) DNA binding (Mitf) protein complex (Mitf)
POU3F2 (Homo sapiens)
Mitf (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 6 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 146 86.00 High High
Injury 2 50.24 Quite High
Cancer 90 5.00 Very Low Very Low Very Low
Metastasis 26 5.00 Very Low Very Low Very Low
Nevus 14 5.00 Very Low Very Low Very Low
Hypoxia 8 5.00 Very Low Very Low Very Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Aggression 4 5.00 Very Low Very Low Very Low
Breast Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, expression of the POU3F2 (BRN2) transcription factor, which was reported to be a negative regulator of MITF expression [22], did not inversely correlate with MITF transcript levels in NZM cell lines (Figure S3).
BRN2 Negative_regulation (regulator) of Gene_expression (expression) of MITF
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.15 Pain Relevance 0
Further, expression of the POU3F2 (BRN2) transcription factor, which was reported to be a negative regulator of MITF expression [22], did not inversely correlate with MITF transcript levels in NZM cell lines (Figure S3).
POU3F2 Negative_regulation (regulator) of Gene_expression (expression) of MITF
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.20 Pain Relevance 0

General Comments

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