INT290477

Context Info Confidence 0.43 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.36 Pain Relevance 0

nucleus (POU3F2, Mitf) pigmentation (Mitf) cell differentiation (Mitf) protein complex assembly (Mitf) DNA binding (Mitf) protein complex (Mitf)

POU3F2 (Homo sapiens) Mitf (Mus musculus)

Pain Link Frequency Relevance Heat metalloproteinase 6 5.00 palliative 2 5.00 depression 2 5.00

Disease Link Frequency Relevance Heat Melanoma 146 86.00 Injury 2 50.24 Cancer 90 5.00 Metastasis 26 5.00 Nevus 14 5.00 Hypoxia 8 5.00 Hypersensitivity 8 5.00 Disease 6 5.00 Aggression 4 5.00 Breast Cancer 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further, expression of the POU3F2 (BRN2) transcription factor, which was reported to be a negative regulator of MITF expression [22], did not inversely correlate with MITF transcript levels in NZM cell lines (Figure S3).

BRN2 Negative_regulation (regulator) of Gene_expression (expression) of MITF

1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.15 Pain Relevance 0

Further, expression of the POU3F2 (BRN2) transcription factor, which was reported to be a negative regulator of MITF expression [22], did not inversely correlate with MITF transcript levels in NZM cell lines (Figure S3).

POU3F2 Negative_regulation (regulator) of Gene_expression (expression) of MITF

2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.20 Pain Relevance 0

General Comments

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