INT290479

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Context Info
Confidence 0.30
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.29
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A, Mitf) nucleus (HIF1A, Mitf) protein complex assembly (Mitf)
DNA binding (Mitf) protein complex (Mitf) cytoplasm (HIF1A)
HIF1A (Homo sapiens)
Mitf (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 6 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Melanoma 2 100.00 Very High Very High Very High
Melanoma 146 99.40 Very High Very High Very High
Cancer 90 72.72 Quite High
Metastasis 26 34.28 Quite Low
Aggression 4 13.48 Low Low
Nevus 14 5.00 Very Low Very Low Very Low
Hypoxia 8 5.00 Very Low Very Low Very Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Breast Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, MITF was shown to bind and transactivate the HIF1a promoter in mouse B16 melanoma cells [29], yet in our study HIF1a was inversely correlated with MITF expression, particularly in the invasive cell lines, suggesting de-regulated MITF and/or cAMP signalling in NZM cells, or that B16 cells may not be a good model of human metastatic melanoma.
HIF1a Binding (bind) of MITF associated with melanoma and experimental melanoma
1) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.61 Pain Relevance 0
For example, MITF was shown to bind and transactivate the HIF1a promoter in mouse B16 melanoma cells [29], yet in our study HIF1a was inversely correlated with MITF expression, particularly in the invasive cell lines, suggesting de-regulated MITF and/or cAMP signalling in NZM cells, or that B16 cells may not be a good model of human metastatic melanoma.
HIF1a Binding (bind) of MITF associated with melanoma and experimental melanoma
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.68 Pain Relevance 0

General Comments

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