INT290483

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (RAB27A, Mitf) cell differentiation (Mitf) Golgi apparatus (RAB27A)
protein complex assembly (Mitf) DNA binding (Mitf) GTPase activity (RAB27A)
RAB27A (Homo sapiens)
Mitf (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 73 95.84 Very High Very High Very High
Experimental Melanoma 1 84.24 Quite High
Cancer 45 55.24 Quite High
Metastasis 13 41.80 Quite Low
Aggression 2 21.00 Low Low
Disease 3 9.12 Low Low
Skin Cancer 2 6.24 Low Low
Nevus 7 5.00 Very Low Very Low Very Low
Hypoxia 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thirty-five of the genes in our 96-gene invasion signature are known or predicted targets of MITF [18], and although experimentally confirmed MITF targets such as MLANA, RAB27A, and GPR143 corresponded closely with MITF expression in our data, some did not, suggesting a disconnect in MITF signalling for some MITF targets in certain melanomas.
RAB27A Regulation (corresponded) of Gene_expression (expression) of MITF associated with melanoma
1) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.64 Pain Relevance 0

General Comments

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