INT29051

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Context Info
Confidence 0.60
First Reported 1987
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 1.29
Pain Relevance 5.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRL1) signal transducer activity (OPRL1)
Anatomy Link Frequency
brain 1
cortex 1
OPRL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 28 100.00 Very High Very High Very High
orphanin 16 100.00 Very High Very High Very High
opiate 7 100.00 Very High Very High Very High
Pain 1 100.00 Very High Very High Very High
antagonist 3 99.96 Very High Very High Very High
agonist 3 99.90 Very High Very High Very High
alcohol 10 99.60 Very High Very High Very High
narcan 10 99.52 Very High Very High Very High
Hyperalgesia 3 99.12 Very High Very High Very High
amygdala 2 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 4 99.12 Very High Very High Very High
Aggression 16 99.04 Very High Very High Very High
Nociception 2 97.44 Very High Very High Very High
Neuroblastoma 2 89.08 High High
Alcohol Addiction 2 78.24 Quite High
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Opiate Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that acute exposure to mu-receptor agonists can regulate ORL1 function, but the ability to do so varies from cell type to cell type.
Regulation (regulate) of ORL1 associated with agonist
1) Confidence 0.60 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12750434 Disease Relevance 0.14 Pain Relevance 0.47
The role of the fourth member of the opioid receptor family, the nociceptin or orphanin FQ receptor (ORL), is not as clear as hyperalgesia, analgesia, and no effect was reported after administration of ORL agonists.
Regulation (role) of ORL associated with hyperalgesia, orphanin, agonist, opioid receptor and analgesia
2) Confidence 0.44 Published 2009 Journal Front. Biosci. Section Abstract Doc Link 19273128 Disease Relevance 0.10 Pain Relevance 1.11
The role of the fourth member of the opioid receptor family, the nociceptin or orphanin FQ receptor (ORL), is not as clear as hyperalgesia, analgesia, and no effect was reported after administration of ORL agonists.
Regulation (role) of orphanin FQ receptor associated with hyperalgesia, orphanin, agonist, opioid receptor and analgesia
3) Confidence 0.42 Published 2009 Journal Front. Biosci. Section Abstract Doc Link 19273128 Disease Relevance 0.10 Pain Relevance 1.11
We determined the effect of the opiate receptor antagonist naloxone on aggression, emotion, feeder control, and eating behavior in high and low aggression female pigeons maintained at 80% of their normal weight and exposed to food competition interactions.
Spec (determined) Regulation (effect) of opiate receptor associated with antagonist, aggression, narcan and opiate
4) Confidence 0.32 Published 2004 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 15060702 Disease Relevance 0.64 Pain Relevance 0.27
The transcription and alternative splicing of human ORL1 are controlled by two alternate promoters, located approximately 10 kb apart.
Regulation (controlled) of ORL1
5) Confidence 0.27 Published 2000 Journal J. Mol. Biol. Section Abstract Doc Link 11090272 Disease Relevance 0 Pain Relevance 0.17
Sensitivity of opioid receptor-like receptor ORL1 for chemical modification on nociceptin, a naturally occurring nociceptive peptide.
Regulation (Sensitivity) of ORL1 associated with nociception, pain, orphanin and opioid receptor
6) Confidence 0.26 Published 1996 Journal J. Biol. Chem. Section Title Doc Link 8798582 Disease Relevance 0.24 Pain Relevance 0.71
Ethanol may modify some opiate receptors, and possibly change the brain tissue endogenous opiate peptide levels in some loci.
Regulation (change) of opiate peptide in brain associated with opiate
7) Confidence 0.23 Published 1987 Journal Adv Alcohol Subst Abuse Section Abstract Doc Link 2821747 Disease Relevance 0.08 Pain Relevance 1.12
Prenatal alcohol exposure primarily influenced the kappa receptor mRNA with reduced levels in the amygdala, claustrum, putamen and insula cortex.
Regulation (influenced) of kappa receptor mRNA in cortex associated with insula, amygdala and alcohol
8) Confidence 0.13 Published 2006 Journal Pharmacogenomics J. Section Abstract Doc Link 16477274 Disease Relevance 0 Pain Relevance 0.85

General Comments

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