INT290523

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Context Info
Confidence 0.81
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 3.10
Pain Relevance 6.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
astrocytes 2
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 530 100.00 Very High Very High Very High
Lasting pain 6 99.78 Very High Very High Very High
Dynorphin 100 98.48 Very High Very High Very High
amygdala 46 97.80 Very High Very High Very High
trigeminal ganglion 132 97.68 Very High Very High Very High
Inflammation 18 96.04 Very High Very High Very High
agonist 34 96.00 Very High Very High Very High
Opioid 93 93.84 High High
Peripheral nerve injury 30 93.12 High High
Central nervous system 145 91.84 High High
Disease Link Frequency Relevance Heat
Pain 26 99.78 Very High Very High Very High
Ganglion Cysts 158 97.68 Very High Very High Very High
INFLAMMATION 18 96.04 Very High Very High Very High
Nervous System Injury 78 93.12 High High
Gliosis 31 92.28 High High
Stress 46 86.00 High High
Anxiety Disorder 46 85.36 High High
Neuropathic Pain 102 85.28 High High
Injury 6 75.00 Quite High
Targeted Disruption 27 50.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we used an antibody which detects the phosphorylated form of kappa opioid receptor to determine the sites of endogenous dynorphin action in TG, TREZ and Vp.
Phosphorylation (phosphorylated) of kappa opioid receptor associated with dynorphin, trigeminal ganglion and kappa opioid receptor
1) Confidence 0.81 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.42 Pain Relevance 1.44
Previous studies [15,16,3] have shown that the sustained release of endogenous dynorphins during chronic pain increased KOR phosphorylation as detected by KOR-p staining.
Phosphorylation (phosphorylation) of KOR associated with lasting pain and kappa opioid receptor
2) Confidence 0.81 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.36 Pain Relevance 1.40
We previously established that activation of KOR results in G-protein receptor kinase mediated phosphorylation of KOR that can be readily detected using a phosphor selective antibody, KOR-p-IR [15].
Phosphorylation (phosphorylation) of KOR associated with kappa opioid receptor
3) Confidence 0.71 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.27 Pain Relevance 0.85
Primary antibody concentrations were as follows: rabbit anti-phosphorylated kappa opioid receptor (20 ?
Phosphorylation (phosphorylated) of kappa opioid receptor associated with kappa opioid receptor
4) Confidence 0.71 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.24 Pain Relevance 0.25
GFAP-positive astrocytes made a clear borderline between the CNS and the PNS in TREZ, and phosphorylated KOR staining (KOR-p) was detectable only in the astrocytes in CNS in WT mice but not in KOR-/- or norBNI-treated mice.


Phosphorylation (phosphorylated) of KOR-p in astrocytes associated with kappa opioid receptor
5) Confidence 0.55 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2826348 Disease Relevance 0.71 Pain Relevance 0.86
GFAP-positive astrocytes made a clear borderline between the CNS and the PNS in TREZ, and phosphorylated KOR staining (KOR-p) was detectable only in the astrocytes in CNS in WT mice but not in KOR-/- or norBNI-treated mice.


Phosphorylation (phosphorylated) of KOR in astrocytes associated with kappa opioid receptor
6) Confidence 0.55 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2826348 Disease Relevance 0.71 Pain Relevance 0.86
Prior work demonstrated that phosphorylation of KOR is mediated by G-protein coupled receptor kinase 3 following receptor activation by the endogenous agonist dynorphin [30].
Phosphorylation (phosphorylation) of KOR associated with dynorphin, agonist and kappa opioid receptor
7) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.38 Pain Relevance 0.68
FAK could phosphorylate Grb7 and thereby release KOR mRNA for translation (Tsai et al., 2007).
Phosphorylation (phosphorylate) of KOR
8) Confidence 0.02 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0

General Comments

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