INT290541

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Context Info
Confidence 0.18
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr3, Oprk1) plasma membrane (Gpr3, Oprk1) signal transducer activity (Gpr3, Oprk1)
Gpr3 (Mus musculus)
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 50 100.00 Very High Very High Very High
agonist 10 98.04 Very High Very High Very High
amygdala 46 97.80 Very High Very High Very High
Dynorphin 49 97.72 Very High Very High Very High
alcohol 1 81.56 Quite High
Nicotine 1 71.28 Quite High
withdrawal 4 70.80 Quite High
antagonist 11 57.00 Quite High
Opioid 3 50.00 Quite Low
Dopamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 45 90.08 High High
Anxiety Disorder 46 89.44 High High
Targeted Disruption 14 50.36 Quite High
Sprains And Strains 1 6.48 Low Low
Depression 3 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Gliosis 1 5.00 Very Low Very Low Very Low
Recurrence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prior work demonstrated that phosphorylation of KOR is mediated by G-protein coupled receptor kinase 3 following receptor activation by the endogenous agonist dynorphin [30].
G-protein coupled receptor kinase 3 Positive_regulation (mediated) of Phosphorylation (phosphorylation) of KOR associated with dynorphin, agonist and kappa opioid receptor
1) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.45 Pain Relevance 0.69

General Comments

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