INT290542

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.36
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Insr) response to stress (Crh) cytoplasm (Crh)
cytosol (Insr) extracellular space (Crh) extracellular region (Crh)
Anatomy Link Frequency
brain 1
Crh (Mus musculus)
Insr (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 92 99.68 Very High Very High Very High
Kappa opioid receptor 100 92.64 High High
Dynorphin 98 88.48 High High
Ventral tegmentum 4 62.84 Quite High
Dopamine 6 59.16 Quite High
Opioid 6 50.00 Quite Low
antagonist 22 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
withdrawal 8 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 92 84.16 Quite High
Stress 90 73.36 Quite High
Targeted Disruption 28 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low
Gliosis 2 5.00 Very Low Very Low Very Low
Recurrence 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Control brain sections from mice stereotaxically injected with saline in the BLA show increased KORp-ir induced by CRF (i.c.v) (Fig. 4B).
CRF Positive_regulation (induced) of KORp-ir in brain associated with amygdala
1) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.06 Pain Relevance 0.64
Antagonism of CRF1-R with a selective dose of antalarmin (10 mg/kg, i.p.) [1] blocked the CRF-induced increase KORp-ir in the BLA (Fig. 4A,D) (one way ANOVA, F(2, 10)?
CRF-induced Positive_regulation (increase) of KORp-ir associated with amygdala
2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.30 Pain Relevance 0.72

General Comments

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