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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.04
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) plasma membrane (Pdyn)
response to stress (Crh) cytoplasm (Crh)
Anatomy Link Frequency
brain 1
Crh (Mus musculus)
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 49 100.00 Very High Very High Very High
Kappa opioid receptor 50 84.60 Quite High
depression 3 78.08 Quite High
agonist 10 53.04 Quite High
amygdala 46 50.00 Quite Low
Opioid 3 50.00 Quite Low
Neuropeptide 2 45.48 Quite Low
Central nervous system 1 36.96 Quite Low
withdrawal 4 32.52 Quite Low
antidepressant 1 23.52 Low Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 46 97.20 Very High Very High Very High
Stress 45 93.56 High High
Depression 3 78.08 Quite High
Targeted Disruption 14 58.56 Quite High
Recurrence 1 31.08 Quite Low
Drug Dependence 1 16.40 Low Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Gliosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we dissected the linkage between the CRF and dynorphin systems in the brain, and studied how these interactions may mediate anxiety-like behaviors.

CRF Binding (linkage) of dynorphin in brain associated with dynorphin and anxiety disorder
1) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 1.04 Pain Relevance 0.43

General Comments

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