INT290548

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Crhr1) plasma membrane (Crhr1) translation (Etf1)
cellular_component (Etf1) cytoplasm (Etf1) response to stress (Crhr1)
Anatomy Link Frequency
BLA 2
Crhr1 (Mus musculus)
Etf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 49 100.00 Very High Very High Very High
amygdala 46 99.20 Very High Very High Very High
Kappa opioid receptor 50 97.00 Very High Very High Very High
Ventral tegmentum 2 84.12 Quite High
Dopamine 3 80.44 Quite High
Opioid 3 50.00 Quite Low
agonist 10 13.40 Low Low
antagonist 11 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 46 96.92 Very High Very High Very High
Stress 45 94.64 High High
Targeted Disruption 14 19.72 Low Low
Depression 3 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Gliosis 1 5.00 Very Low Very Low Very Low
Recurrence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The anxiogenic-like effects of CRF and stressin 1 suggest that CRF1-R receptor activation induces dynorphin release in the basolateral amygdala (BLA), a brain region regarded as necessary for anxiety-like behaviors [36].
Positive_regulation (activation) of CRF1-R in BLA Positive_regulation (induces) of release associated with dynorphin, anxiety disorder and amygdala
1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.38 Pain Relevance 0.72

General Comments

This test has worked.

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