INT290552

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Context Info
Confidence 0.38
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.23
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) plasma membrane (Pdyn)
response to stress (Crh) cytoplasm (Crh)
Crh (Mus musculus)
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 49 100.00 Very High Very High Very High
Kappa opioid receptor 50 99.96 Very High Very High Very High
antagonist 11 88.84 High High
amygdala 46 50.00 Quite Low
Opioid 3 50.00 Quite Low
agonist 10 27.28 Quite Low
withdrawal 4 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Ventral tegmentum 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 46 82.48 Quite High
Stress 45 79.92 Quite High
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Gliosis 1 5.00 Very Low Very Low Very Low
Recurrence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that the anxiogenic-like effects of CRF require activation of the dynorphin/KOR system.
CRF Positive_regulation (require) of Positive_regulation (activation) of dynorphin associated with dynorphin and kappa opioid receptor
1) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.23 Pain Relevance 0.30

General Comments

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