INT290556

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (MLH1, MSH2) nucleus (MLH1, MSH2) nuclear chromosome (MSH2)
enzyme binding (MSH2) DNA binding (MSH2) cell cycle (MLH1)
Anatomy Link Frequency
MLH1 3
MLH1 (Homo sapiens)
MSH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 5 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ureteral Neoplasms 24 99.92 Very High Very High Very High
Carcinoma 18 99.04 Very High Very High Very High
Adenocarcinoma 6 98.08 Very High Very High Very High
Colon Cancer 39 92.28 High High
Syndrome 23 90.36 High High
Hereditary Nonpolyposis Colorectal Neoplasms 13 89.40 High High
Cancer 75 88.48 High High
Colorectal Cancer 51 84.60 Quite High
Adenoma 4 83.16 Quite High
Hereditary Neoplastic Syndromes 2 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ureteral neoplasms in HNPCC are most often associated with mutations in MSH2 and rarely with mutations in MLH1.
HNPCC Binding (associated) of MSH2 in MLH1 associated with ureteral neoplasms
1) Confidence 0.34 Published 2009 Journal World J Surg Oncol Section Abstract Doc Link PMC2795749 Disease Relevance 0.85 Pain Relevance 0
Since the discovery of the major human gene with DNA misrepair function in 1993-1995, mutations in MSH2, MLH1, MSH6 and PMS2 have been convincingly associated with HNPCC.
HNPCC Binding (associated) of MSH2 in MLH1
2) Confidence 0.32 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837058 Disease Relevance 0.53 Pain Relevance 0
About 90% of HNPCC cases are associated with mutations in MLH1 (OMIM #120436) or MSH2 (OMIM #609309), and others are associated with mutations in MSH6, PMS1, PMS2, and MLH3 [4].
HNPCC Binding (associated) of MSH2 in MLH1
3) Confidence 0.30 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2795749 Disease Relevance 1.36 Pain Relevance 0

General Comments

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