INT29056

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Context Info
Confidence 0.60
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.47
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Anatomy Link Frequency
platelet 2
Alox5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 1 99.66 Very High Very High Very High
Hyperesthesia 1 99.38 Very High Very High Very High
Hyperalgesia 3 98.20 Very High Very High Very High
Inflammation 14 95.92 Very High Very High Very High
Pain 1 92.76 High High
Kinase C 2 78.28 Quite High
Inflammatory mediators 2 75.28 Quite High
IPN 1 65.32 Quite High
cytokine 7 36.92 Quite Low
Inflammatory stimuli 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperalgesia 4 98.20 Very High Very High Very High
INFLAMMATION 26 95.92 Very High Very High Very High
Nociception 1 94.44 High High
Pain 1 92.76 High High
Leukemia 1 86.72 High High
Breast Cancer 16 84.00 Quite High
Cancer 11 77.64 Quite High
Apoptosis 13 76.52 Quite High
Hepatotoxicity 10 74.12 Quite High
Stress 5 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence for the involvement of 5-lipoxygenase products in the regulation of the expression of the proenkephalin gene in cultured astroglial cells.
Regulation (involvement) of Gene_expression (products) of 5-lipoxygenase associated with enkephalin
1) Confidence 0.60 Published 1995 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8774948 Disease Relevance 0 Pain Relevance 0.14
Pharmacological evidence for a role of lipoxygenase products in platelet-activating factor (PAF)-induced hyperalgesia.
Regulation (role) of Gene_expression (products) of lipoxygenase in platelet associated with hyperesthesia and hyperalgesia
2) Confidence 0.06 Published 1987 Journal Biochem. Pharmacol. Section Title Doc Link 2822047 Disease Relevance 0.54 Pain Relevance 0.55
AA, which regulates the production of lipoxygenase, COX and cytochrome P-450 epoxygenase products could impact many of the pharmacological actions of these two selective estrogen receptor modulators.
Regulation (regulates) of Gene_expression (production) of lipoxygenase
3) Confidence 0.01 Published 2004 Journal BMC Cancer Section Body Doc Link PMC514706 Disease Relevance 0.55 Pain Relevance 0
No change was observed in lipoxygenase expression, but phospholipase A1 (Pla1a) was increased in all rats treated with TNF?
Neg (No) Regulation (change) of Gene_expression (expression) of lipoxygenase
4) Confidence 0.01 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000109 Disease Relevance 0.37 Pain Relevance 0.04

General Comments

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