INT290579

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.59
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pou5f1) nucleoplasm (Pou5f1) nucleus (Pou5f1)
DNA binding (Pou5f1) transcription factor binding (Pou5f1) cytoplasm (Pou5f1)
Anatomy Link Frequency
brain 1
Pou5f1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 16 94.96 High High
Central nervous system 8 81.44 Quite High
neurotrophin 3 8 77.56 Quite High
long-term potentiation 1 74.64 Quite High
Action potential 7 14.08 Low Low
Potency 1 10.24 Low Low
anesthesia 3 5.20 Low Low
imagery 13 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
positron emission tomography 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 48 92.44 High High
Cytomegalovirus Infection 56 91.80 High High
Cancer 4 89.28 High High
Teratoma 4 85.44 High High
Embryonal Carcinoma 23 72.88 Quite High
Apoptosis 5 70.72 Quite High
Sprains And Strains 1 64.64 Quite High
Neurodegenerative Disease 6 50.00 Quite Low
Intellectual Impairment 3 34.72 Quite Low
Injury 16 25.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, colonies of undifferentiated ESCs and high expression levels of Nanog and Pou5f1 were found in cultures of the sorted GFP(?)
Negative_regulation (levels) of Pou5f1
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.34 Pain Relevance 0
This neuronal loss was associated with down-regulation of multipotency marker, Oct4 and neurotrophins, indicating abnormal brain development.


Negative_regulation (regulation) of Oct4 in brain
2) Confidence 0.25 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 1.04 Pain Relevance 0.15
In contrast, the embryonic marker Oct-4 was downregulated during hESC-EC differentiation (data not show).
Negative_regulation (downregulated) of Oct-4
3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
The differentiation process in cells induced by OT and OT-GKR was indicated by loss of OCT-4 immunostaining, a marker of the undifferentiated state (Figs. 7A-A4).
Negative_regulation (loss) of OCT-4
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.20 Pain Relevance 0.05

General Comments

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