INT290634

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.34
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton organization (Ccl24) molecular_function (Ccl24) cellular_component (Ccl24)
biological_process (Ccl24)
Anatomy Link Frequency
eosinophils 1
Ccl24 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 122 98.58 Very High Very High Very High
antagonist 18 90.96 High High
Inflammation 13 85.92 High High
withdrawal 2 60.16 Quite High
chemokine 2 54.56 Quite High
cINOD 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eosinophilia 2 99.16 Very High Very High Very High
Asthma 85 99.12 Very High Very High Very High
Rhinitis 24 98.16 Very High Very High Very High
Respiratory Disease 84 97.00 Very High Very High Very High
Hypersensitivity 14 93.10 High High
Occupational Lung Diseases 6 86.36 High High
INFLAMMATION 18 85.92 High High
Obesity 4 73.68 Quite High
Bronchospasm 17 50.00 Quite Low
Sinusitis 8 30.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eosinophils and mast cells show marked infiltration into the bronchial tree and nasal polyps in AIA and are important cell types in aspirin hypersensitivity of the airways.27,28 Endobronchial aspirin challenge induced a decrease in the number of mast cells that stained for tryptase and an increase in the number of activated eosinophils, which reflects degranulation of these cell types and an early event associated with aspirin-sensitive reactions in AIA subjects.29 Elevated levels of eotaxin and eotaxin-2 expression characterize tissue eosinophilia,30 and these levels are changed after aspirin challenge.31 In addition, both CYSLT1R and CYSLT2R are expressed on eosinophils, especially during exacerbation of asthma.32 Leukotriene receptor antagonists are effective in treating AIA, because they inhibit the production of leukotrienes and the degree of eosinophilic inflammation in the airways.33 Therefore, airway eosinophilia may be a critical marker for responsiveness.
Gene_expression (expression) of eotaxin-2 in eosinophils associated with asthma, aspirin, rhinitis, inflammation, antagonist, hypersensitivity and eosinophilia
1) Confidence 0.01 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2831603 Disease Relevance 1.30 Pain Relevance 0.40
The CRTH2 -466T > C polymorphism could increase serum and cellular eotaxin-2 production through lowered CRTH2 expression, leading to eosinophilic infiltration in AERD patients.26
Gene_expression (production) of eotaxin-2 associated with rhinitis and respiratory disease
2) Confidence 0.01 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2796398 Disease Relevance 1.05 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox