INT29064

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Context Info
Confidence 0.77
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 14
Disease Relevance 2.48
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1)
endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)
Anatomy Link Frequency
retina 4
brain 2
amacrine cells 1
ganglia 1
Sigmar1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 7 99.98 Very High Very High Very High
agonist 6 99.96 Very High Very High Very High
GABAergic 6 97.00 Very High Very High Very High
fortral 25 96.16 Very High Very High Very High
Kinase C 6 94.76 High High
Calcium channel 8 93.36 High High
potassium channel 6 91.52 High High
antagonist 3 89.24 High High
Clonidine 1 88.96 High High
Eae 1 77.08 Quite High
Disease Link Frequency Relevance Heat
Movement Disorders 2 99.80 Very High Very High Very High
Dystonia 2 99.10 Very High Very High Very High
Ganglion Cysts 17 98.68 Very High Very High Very High
Dyskinesias 1 95.60 Very High Very High Very High
Death 7 94.80 High High
Neurodegenerative Disease 1 94.60 High High
Schizophrenia 1 89.16 High High
Apoptosis 3 86.24 High High
Toxicity 3 74.80 Quite High
Drug Induced Neurotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of sigma receptor 1 mRNA and protein in rat retina.
Gene_expression (Expression) of sigma receptor 1 mRNA in retina
1) Confidence 0.77 Published 2010 Journal Neuroscience Section Title Doc Link 20223280 Disease Relevance 0.07 Pain Relevance 0.17
In contrast, no sigmaR1-IR was detected in several subtypes of bipolar cells, including rod-dominant ON-type bipolar cells, types 2, 3, 5 and 8 bipolar cells, labeled by protein kinase C (PKC), recoverin and hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 (HCN4) respectively.
Gene_expression (detected) of sigmaR1 associated with kinase c and potassium channel
2) Confidence 0.77 Published 2010 Journal Neuroscience Section Abstract Doc Link 20223280 Disease Relevance 0.10 Pain Relevance 0.21
In this work, we examined the expression of sigmaR1 in rat retina by reverse transcription-polymerase chain reactive (RT-PCR) analysis and immunofluorescence double labeling.
Spec (examined) Gene_expression (expression) of sigmaR1 in retina
3) Confidence 0.77 Published 2010 Journal Neuroscience Section Abstract Doc Link 20223280 Disease Relevance 0.07 Pain Relevance 0.10
In the inner retina, most of GABAergic amacrine cells, including dopaminergic and cholinergic ones, stained by tyrosine hydroxylase (TH) and choline acetyltransferase (ChAT) respectively, expressed sigmaR1.
Gene_expression (expressed) of sigmaR1 in amacrine cells associated with gabaergic
4) Confidence 0.77 Published 2010 Journal Neuroscience Section Abstract Doc Link 20223280 Disease Relevance 0.16 Pain Relevance 0.19
RT-PCR analysis showed that sigmaR1 mRNA was present in rat retina.
Gene_expression (present) of sigmaR1 mRNA in retina
5) Confidence 0.77 Published 2010 Journal Neuroscience Section Abstract Doc Link 20223280 Disease Relevance 0.08 Pain Relevance 0.15
In the outer retina sigmaR1 was expressed in all horizontal cells labeled by calbindin.
Gene_expression (expressed) of sigmaR1 in retina
6) Confidence 0.68 Published 2010 Journal Neuroscience Section Abstract Doc Link 20223280 Disease Relevance 0.10 Pain Relevance 0.19
Semiquantitative RT-PCR and immunocytochemical analysis demonstrated that RGC-5 cells were exposed to homocysteine or glutamate express type 1 sigma receptor at levels similar to control cells.
Gene_expression (express) of type 1 sigma receptor associated with glutamate
7) Confidence 0.60 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15046867 Disease Relevance 1.18 Pain Relevance 0.65
Individual neurons from SCG and intracardiac ganglia were shown to express transcripts encoding the sigma-1 receptor using single-cell RT-PCR techniques.
Gene_expression (express) of sigma-1 receptor in ganglia
8) Confidence 0.59 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12037190 Disease Relevance 0.07 Pain Relevance 0.21
The sigma ligand JO 1784 prevents trimethyltin-induced behavioural and sigma-receptor dysfunction in the rat.
Gene_expression (dysfunction) of sigma-receptor
9) Confidence 0.48 Published 1996 Journal Pharmacol. Toxicol. Section Title Doc Link 8737963 Disease Relevance 0.09 Pain Relevance 0.23
In prior in vivo studies, it has been shown to attenuate the dystonic postures and orofacial dyskinesias that are produced by sigma receptor ligands, including the neuroleptic haloperidol.
Gene_expression (produced) of sigma receptor associated with movement disorders and dystonia
10) Confidence 0.41 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9137911 Disease Relevance 0.48 Pain Relevance 0.03
Functional expression of the cloned rat brain sigma receptor in HeLa cells also leads to an increase in the binding of two other sigma ligands, namely, (+)-pentazocine and (+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine (PPP).
Gene_expression (expression) of brain sigma receptor in brain associated with fortral
11) Confidence 0.26 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9489711 Disease Relevance 0 Pain Relevance 0.10
When expressed in HeLa cells, the rat brain sigma receptor cDNA leads to a two- to threefold increase in haloperidol binding, and this cDNA-induced binding is sensitive to inhibition by several sigma receptor-specific ligands.
Gene_expression (expressed) of brain sigma receptor in brain
12) Confidence 0.23 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9489711 Disease Relevance 0 Pain Relevance 0.06
The role of the dopaminergic, noradrenergic and serotonergic systems in the production of the discriminative stimulus (DS) properties of the sigma receptor agonist (+)-N-allylnormetazocine [(+)-NANM/(+)-SKF 10,047] was measured in rats.
Gene_expression (production) of sigma receptor associated with agonist
13) Confidence 0.23 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2822445 Disease Relevance 0 Pain Relevance 0.28
[Functional characterization of a sigma receptor and its gene expression by haloperidol].
Gene_expression (expression) of sigma receptor
14) Confidence 0.06 Published 1999 Journal Nippon Yakurigaku Zasshi Section Title Doc Link 10562966 Disease Relevance 0.09 Pain Relevance 0.09

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