INT290667

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.42
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Stat3) cytoplasm (Stat3) signal transducer activity (Stat3)
cell proliferation (Stat3) extracellular space (Il6) signal transduction (Stat3)
Anatomy Link Frequency
macrophages 2
thyroid 1
Il6 (Mus musculus)
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 28 99.64 Very High Very High Very High
Inflammation 212 98.04 Very High Very High Very High
cytokine 90 89.92 High High
chemokine 6 42.56 Quite Low
Inflammatory mediators 12 32.40 Quite Low
agonist 20 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 246 99.46 Very High Very High Very High
Colitis 42 86.24 High High
Multiple Myeloma 4 79.68 Quite High
Cancer 340 64.00 Quite High
Repression 14 57.88 Quite High
Targeted Disruption 16 50.76 Quite High
Adhesions 8 44.04 Quite Low
Hypoxia 2 27.96 Quite Low
Death 4 13.84 Low Low
Apoptosis 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, transient Stat3 activation by IL6 in wild-type macrophages promotes an inflammatory response, while sustained Stat3 activation by IL6 of gp130Y757F mutant macrophages suppresses the inflammatory gene response through the induction of transcriptional repressors [39,40].
IL6 Positive_regulation (activation) of Stat3 in macrophages associated with inflammatory response and inflammation
1) Confidence 0.69 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.80 Pain Relevance 0.40
Accordingly, transient Stat3 activation by IL6 in wild-type macrophages promotes an inflammatory response, while sustained Stat3 activation by IL6 of gp130Y757F mutant macrophages suppresses the inflammatory gene response through the induction of transcriptional repressors [39,40].
IL6 Positive_regulation (activation) of Stat3 in macrophages associated with inflammatory response and inflammation
2) Confidence 0.50 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.79 Pain Relevance 0.40
For example, IL-6 signaling also activates the STAT3 pathway but is incapable of activating the anti-inflammatory response.
IL-6 Positive_regulation (activates) of STAT3 associated with inflammatory response
3) Confidence 0.09 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.45 Pain Relevance 0.16
ligands suppress IL-6 activated STAT3 through various types of crosstalk including direct or mediated by the corepressor SMRT (silencing mediator of retinoid and thyroid hormone receptor).
IL-6 Positive_regulation (activated) of STAT3 in thyroid
4) Confidence 0.09 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.38 Pain Relevance 0.20

General Comments

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