INT290684

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Context Info
Confidence 0.78
First Reported 2010
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 1
Total Number 29
Disease Relevance 1.78
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

growth (FOXP2) nucleolus (FOXP2) nucleus (FOXP2)
intracellular (FOXP2) embryo development (FOXP2) DNA binding (FOXP2)
Anatomy Link Frequency
juveniles 5
brain 3
striatum 2
neurons 1
FOXP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 29 52.04 Quite High
anesthesia 29 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Deafness 290 99.08 Very High Very High Very High
Congenital Anomalies 58 93.76 High High
Language Disorders 29 91.20 High High
Ganglion Cysts 29 77.00 Quite High
Decapitation 58 72.32 Quite High
Targeted Disruption 29 48.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differences in the probes used to detect FoxP2 in the two studies may contribute to the different findings.
Gene_expression (detect) of FoxP2
1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
To test the effect of singing on FoxP2 expression during sensorimotor learning in the presence or absence of auditory feedback, juvenile males were deafened at 35d.
Gene_expression (expression) of FoxP2 in juvenile
2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0.06 Pain Relevance 0
We tested whether deafening prior to or during the sensorimotor phase of song learning disrupted FoxP2 expression in song circuitry.
Gene_expression (expression) of FoxP2
3) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2796720 Disease Relevance 0.30 Pain Relevance 0
To determine whether or not FoxP2 down-regulation by singing in juveniles depends on auditory feedback, 75d deafened birds were allowed to sing for 2 hours and examined FoxP2 expression levels in area X.
Spec (examined) Gene_expression (expression) of FoxP2 in juveniles
4) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
FoxP2 expression in area X of multiple coronal or sagittal brain sections was quantified from digitized images of film autoradiograms using Adobe Photoshop 7.0 (Adobe Systems Inc.
Gene_expression (expression) of FoxP2 in brain
5) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
The persistent expression of FoxP2 observed here during late sensorimotor learning, the high levels of expression during human [14] and songbird embryogenesis [15], the FoxP2 immunoreactivity observed within newly generated neurons in area X [16], and the structural brain deficits in humans bearing FOXP2 mutations [41] are all consistent with a role for this molecule in the formation of certain brain regions, including the striatum.
Gene_expression (expression) of FoxP2 in brain
6) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
To examine the effect of auditory deprivation on FoxP2 expression, a cohort of the birds were deafened at either 25 or 35d (Fig. 1A).
Spec (examine) Gene_expression (expression) of FoxP2
7) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0.07 Pain Relevance 0
Although chronic auditory deprivation during sensorimotor learning produced abnormal songs, it did not alter basal FoxP2 expression levels.
Gene_expression (expression) of FoxP2
8) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0.07 Pain Relevance 0
FoxP2 levels appear to increase in the song nucleus, area X, of developing zebra finches at 35 and 50d [15], followed by an increase in area X volume and the number of new neurons expressing FoxP2 protein at 50 and 75d [16].
Gene_expression (expressing) of FoxP2 in neurons
9) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0.14 Pain Relevance 0
We previously found parallel FoxP2 expression patterns in human and songbird cortico/pallio-striatal circuits important for learned vocalizations, suggesting that FoxP2's function in birdsong may generalize to speech.


Gene_expression (expression) of FoxP2
10) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2796720 Disease Relevance 0.18 Pain Relevance 0
Because motor-driven gene expression can occur outside of area X for non-singing behaviors [39], we additionally measured FoxP2 expression levels in a nidopallial region (outside of LMAN) on the same section and used these values for normalization.
Gene_expression (expression) of FoxP2
11) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
FoxP2 is expressed in the striatum of human embryos and of 1 day post hatch (1d) zebra finches [14].
Gene_expression (expressed) of FoxP2 in striatum
12) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0.13 Pain Relevance 0
Deafening of young birds either shortly before or at the onset of sensorimotor learning did not affect the basal expression pattern of FoxP2 in area X at any of the three ages tested (Fig. 2) despite the expected disruption of song development [32], [40].
Gene_expression (expression) of FoxP2
13) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0.06 Pain Relevance 0
Akin to the prior analysis, FoxP2 levels in area X were down-regulated by singing when nidopallial areas were used for normalization (3?
Gene_expression (levels) of FoxP2
14) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
As expected, the songs of deafened juveniles were abnormal, however basal FoxP2 levels were unaffected.
Gene_expression (levels) of FoxP2 in juveniles
15) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2796720 Disease Relevance 0.31 Pain Relevance 0
Interestingly, unlike the hearing group in which FoxP2 levels were correlated with the amount of singing (see above), no correlation was found for the deafened group (Spearman Rho p?
Gene_expression (levels) of FoxP2
16) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
It follows that FoxP2 levels are also more frequently low during late sensorimotor learning, when song is still changing, than in adulthood, when song is more stable.
Gene_expression (levels) of FoxP2
17) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0.03
The developmental changes in FoxP2 expression levels shown here contrast slightly with a trend reported by Haesler et al. (2004) [15].
Gene_expression (expression) of FoxP2
18) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
In slight contrast, FoxP2 levels detected by the mid-probe, designed to recognize both long and truncated forms of the molecule, exhibited a transient decrease at 65d followed by an increase at 75d (H?
Gene_expression (levels) of FoxP2
19) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
Thus, in cases where we observed singing-driven regulation of FoxP2 in area X using outlying striatum as a control tissue for normalization, we additionally measured FoxP2 levels in nidopallial regions of the same section (outside of LMAN) and used these for normalization.


Gene_expression (levels) of FoxP2 in striatum
20) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0

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