INT290686

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Context Info
Confidence 0.62
First Reported 2010
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 0.63
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

growth (FOXP2) nucleolus (FOXP2) nucleus (FOXP2)
intracellular (FOXP2) embryo development (FOXP2) DNA binding (FOXP2)
Anatomy Link Frequency
juveniles 4
brain 2
FOXP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 10 24.96 Low Low
anesthesia 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Deafness 100 97.52 Very High Very High Very High
Decapitation 20 73.68 Quite High
Congenital Anomalies 20 66.08 Quite High
Language Disorders 10 63.52 Quite High
Targeted Disruption 10 26.88 Quite Low
Ganglion Cysts 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine the effect of auditory deprivation on FoxP2 expression, a cohort of the birds were deafened at either 25 or 35d (Fig. 1A).
Spec (examine) Regulation (effect) of Spec (examine) Gene_expression (expression) of FoxP2
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0.07 Pain Relevance 0
To test the effect of singing on FoxP2 expression during sensorimotor learning in the presence or absence of auditory feedback, juvenile males were deafened at 35d.
Regulation (effect) of Gene_expression (expression) of FoxP2 in juvenile
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0.06 Pain Relevance 0
Deafening of young birds either shortly before or at the onset of sensorimotor learning did not affect the basal expression pattern of FoxP2 in area X at any of the three ages tested (Fig. 2) despite the expected disruption of song development [32], [40].
Neg (not) Regulation (affect) of Gene_expression (expression) of FoxP2
3) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0.06 Pain Relevance 0
20% of area X was affected, so presumably FoxP2 levels were normally regulated in the remaining portion.
Regulation (regulated) of Gene_expression (levels) of FoxP2
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
As expected, the songs of deafened juveniles were abnormal, however basal FoxP2 levels were unaffected.
Neg (unaffected) Regulation (unaffected) of Gene_expression (levels) of FoxP2 in juveniles
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2796720 Disease Relevance 0.31 Pain Relevance 0
Overall, birds may tacitly ‘self-regulate’ their own FoxP2 levels, depending on how often they engage in vocal motor practice, a relationship that may extend to other learned motor skills and other transcription factors
Spec (may) Regulation (regulate) of Gene_expression (levels) of FoxP2
6) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
Overall, birds may tacitly ‘self-regulate’ their own FoxP2 levels, depending on how often they engage in vocal motor practice, a relationship that may extend to other learned motor skills and other transcription factors
Regulation (depending) of Gene_expression (levels) of FoxP2
7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
The persistent expression of FoxP2 observed here during late sensorimotor learning, the high levels of expression during human [14] and songbird embryogenesis [15], the FoxP2 immunoreactivity observed within newly generated neurons in area X [16], and the structural brain deficits in humans bearing FOXP2 mutations [41] are all consistent with a role for this molecule in the formation of certain brain regions, including the striatum.
Regulation (immunoreactivity) of Gene_expression (expression) of FoxP2 in brain
8) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
Although chronic auditory deprivation during sensorimotor learning produced abnormal songs, it did not alter basal FoxP2 expression levels.
Neg (not) Regulation (alter) of Gene_expression (expression) of FoxP2
9) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0.07 Pain Relevance 0
The effect of auditory deprivation on FoxP2 expression was analyzed using the Kruskal-Wallis test for more than two groups, and the test statistic (H) with degrees of freedom (df) are reported in the relevant figure legends, or in the text in those cases where there is no figure.
Spec (analyzed) Regulation (effect) of Gene_expression (expression) of FoxP2
10) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0.07 Pain Relevance 0

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