INT290688

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 18
Disease Relevance 1.11
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

growth (FOXP2) nucleolus (FOXP2) nucleus (FOXP2)
intracellular (FOXP2) embryo development (FOXP2) DNA binding (FOXP2)
Anatomy Link Frequency
juveniles 7
nucleus 2
FOXP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 18 72.96 Quite High
anesthesia 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Deafness 180 99.08 Very High Very High Very High
Targeted Disruption 18 69.24 Quite High
Congenital Anomalies 36 66.08 Quite High
Language Disorders 18 63.52 Quite High
Ganglion Cysts 18 10.32 Low Low
Decapitation 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, it may be that nighttime ‘song rehearsal’ [46] also decreases FoxP2 levels.
Negative_regulation (decreases) of FoxP2
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
Interestingly, singing decreased FoxP2 in both hearing and deafened birds, however, levels were only correlated with the amount of singing in hearing birds.
Negative_regulation (decreased) of FoxP2
2) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
Song practice during the day likely decreased area X FoxP2, at least transiently, in these juveniles, although the full circadian rhythm of FoxP2 levels relative to singing is not yet determined.
Negative_regulation (decreased) of FoxP2 in juveniles
3) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
Similar to hearing birds, singing also decreased FoxP2 in deafened birds relative to basal levels (3?
Negative_regulation (decreased) of FoxP2
4) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
In this case, reduction of FoxP2 might be similar or greater in juveniles, as they make greater modifications to their songs during learning.
Negative_regulation (reduction) of FoxP2 in juveniles
5) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
In contrast, when hearing or deaf juveniles sang for two hours in the morning, FoxP2 was acutely down-regulated in the striatal song nucleus, area X.
Negative_regulation (down) of FoxP2 in nucleus associated with deafness
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2796720 Disease Relevance 0.31 Pain Relevance 0
As expected, the songs of deafened juveniles were abnormal, however basal FoxP2 levels were unaffected.
Neg (unaffected) Negative_regulation (unaffected) of FoxP2 in juveniles
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2796720 Disease Relevance 0.31 Pain Relevance 0
Thus, the FoxP2 down-regulation observed in area X of adult zebra finches cannot be due to developing new songs or to significant restructuring of song circuitry.
Negative_regulation (down-regulation) of FoxP2
8) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0.06 Pain Relevance 0
Another difference between adults and juveniles is the stronger link between the amount of song sung and how readily FoxP2 levels decrease at younger ages.
Negative_regulation (decrease) of FoxP2 in juveniles
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
In contrast, when hearing or deaf juveniles sang for two hours in the morning, FoxP2 was acutely down-regulated in the striatal song nucleus, area X.
Negative_regulation (regulated) of FoxP2 in nucleus associated with deafness
10) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2796720 Disease Relevance 0.31 Pain Relevance 0
Previously, we considered whether the singing driven down-regulation of FoxP2 observed in adults [21] was related to the stereotyped nature of these songs or, alternatively, to their ongoing subtle variability.
Negative_regulation (regulation) of FoxP2
11) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0.12 Pain Relevance 0.04
However, the extent of FoxP2 down-regulation in juveniles was qualitatively similar to that seen for adults [21].
Negative_regulation (down) of FoxP2 in juveniles
12) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
However, the extent of FoxP2 down-regulation in juveniles was qualitatively similar to that seen for adults [21].
Negative_regulation (regulation) of FoxP2 in juveniles
13) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
We found that when juveniles sang, FoxP2 levels in area X declined, similar to what we previously reported for adults.
Negative_regulation (declined) of FoxP2 in juveniles
14) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
In the latter study, chronic down-regulation of FoxP2 using RNA interference resulted in more variable songs of 90d experimental birds relative to age-matched controls.
Negative_regulation (regulation) of FoxP2
15) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
Alternatively, acute FoxP2 down-regulation in adults might enable subtle adjustments involved in song maintenance.
Negative_regulation (down-regulation) of FoxP2
16) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
We then tested for acute down-regulation of FoxP2 in area X of 75 d birds as a function of singing for two hours in the morning.
Negative_regulation (regulation) of FoxP2
17) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0
The naturally-driven down-regulation by singing observed here complements results from experimentally-induced constitutive down-regulation of FoxP2 during sensorimotor learning [47].
Negative_regulation (regulation) of FoxP2
18) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2796720 Disease Relevance 0 Pain Relevance 0

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