INT290793

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.48
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (Clock) DNA binding (Clock) cytoplasm (Clock)
signal transducer activity (Clock) signal transduction (Clock) chromosome (Clock)
Anatomy Link Frequency
nucleus 2
Clock (Mus musculus)
Pain Link Frequency Relevance Heat
endometriosis 9 94.36 High High
Angina 1 17.96 Low Low
tetrodotoxin 18 12.16 Low Low
imagery 10 7.12 Low Low
agonist 8 5.00 Very Low Very Low Very Low
Eae 7 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Dismenorea 6 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 81 100.00 Very High Very High Very High
Affective Disorder 6 99.84 Very High Very High Very High
Targeted Disruption 23 99.76 Very High Very High Very High
Repression 5 98.60 Very High Very High Very High
Endometriosis (extended) 12 94.36 High High
Breast Cancer 51 87.48 High High
Reprotox - General 1 9 85.04 High High
Disease 23 69.28 Quite High
Cancer 36 30.32 Quite Low
Aging 3 26.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The products of these genes interact to form repressor complexes which translocate into the nucleus and inhibit Bmal1-CLOCK/NPAS2 activity, thus resulting in repression of their own transcription [7].
Negative_regulation (inhibit) of CLOCK in nucleus associated with repression
1) Confidence 0.39 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.10 Pain Relevance 0
This was replaced by a binding event of CLOCK:BMAL to the promoter.
Negative_regulation (event) of CLOCK
2) Confidence 0.32 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2953532 Disease Relevance 0 Pain Relevance 0
Alterations or disruptions of biological rhythms, as commonly occurs in shift work, jet lag, sleep deprivation, or clock gene knock out models, are linked to significant disruptions in reproductive function.
Negative_regulation (deprivation) of clock associated with targeted disruption and sleep disorders
3) Confidence 0.24 Published 2010 Journal International Journal of Endocrinology Section Abstract Doc Link PMC2834958 Disease Relevance 0.54 Pain Relevance 0
Transfecting these cells with an altered CLOCK protein (Clock?
Negative_regulation (altered) of Clock
4) Confidence 0.24 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2834958 Disease Relevance 0.13 Pain Relevance 0
This gene is correlated with mood disorders and in Clock mutant mice estrous cyclicity is impaired [76, 80].
Negative_regulation (impaired) of Clock associated with affective disorder
5) Confidence 0.24 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2834958 Disease Relevance 0.65 Pain Relevance 0.09
PER and CRY proteins are classically thought to translocate into the nucleus to inhibit CLOCK?
Negative_regulation (inhibit) of CLOCK in nucleus
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0.06 Pain Relevance 0

General Comments

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