INT290813

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Arntl, Clock) cytoplasm (Arntl, Clock) signal transducer activity (Arntl, Clock)
signal transduction (Arntl, Clock) nucleus (Arntl, Clock) transcription factor binding (Arntl, Clock)
Anatomy Link Frequency
limb 2
Arntl (Mus musculus)
Clock (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 5 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 1 37.60 Quite Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Premature Aging 1 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The positive limb of the mammalian clock machinery is comprised of CLOCK and BMAL1, which are transcription factors that heterodimerize through the PAS domain and induce the expression of clock-controlled genes by binding to their promoters at E-boxes.
BMAL1 Positive_regulation (induce) of Gene_expression (expression) of clock-controlled in limb
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0

General Comments

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