INT290820

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.09
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CRX)
Anatomy Link Frequency
brain 4
CRX (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 88 99.44 Very High Very High Very High
Pain 8 94.88 High High
imagery 38 86.56 High High
nud 2 69.60 Quite High
spastic colon 34 39.92 Quite Low
Visceral pain 6 31.68 Quite Low
Central grey 4 26.48 Quite Low
Locus ceruleus 2 13.76 Low Low
central sensitization 2 13.44 Low Low
Raphe 4 12.64 Low Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

120 100.00 Very High Very High Very High
Pain 12 94.88 High High
Stress 20 94.68 High High
Anxiety Disorder 24 94.52 High High
Dyspepsia 2 69.60 Quite High
Functional Bowel Disorder 4 35.56 Quite Low
Congenital Anomalies 6 32.04 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

6 31.68 Quite Low
Urological Neuroanatomy 4 26.48 Quite Low
Nociception 2 6.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies claimed to have performed functional brain activation in unrestrained conscious rats in response to CRD [47], however the results from these studies must be treated with caution.
Positive_regulation (activation) of Positive_regulation (response) of CRD in brain
1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.46 Pain Relevance 0.07
These data indicate that chronic exposure of the amygdala to elevated levels of CORT enhances overall brain activation in response to CRD, and identified other specific brain regions activated in response to mechanical distension of the colon.
Positive_regulation (enhances) of Positive_regulation (activation) of CRD in brain associated with amygdala
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2797306 Disease Relevance 0.24 Pain Relevance 0.32

General Comments

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