INT290829

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.18
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Napb) vesicle-mediated transport (Napb)
Napb (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 132 98.04 Very High Very High Very High
antidepressant 52 85.64 High High
monoamine 2 85.64 High High
Pyramidal cell 20 79.44 Quite High
antagonist 12 70.32 Quite High
Desipramine 8 49.60 Quite Low
fluoxetine 6 49.08 Quite Low
Neurotransmitter 10 38.76 Quite Low
Glutamate receptor 4 35.32 Quite Low
addiction 2 11.68 Low Low
Disease Link Frequency Relevance Heat
Stress 218 94.04 High High
Urological Neuroanatomy 12 93.72 High High
Anxiety Disorder 8 48.60 Quite Low
Disease 8 31.44 Quite Low
Shock 6 5.00 Very Low Very Low Very Low
Schizophrenia 2 5.00 Very Low Very Low Very Low
Suicidal Behaviour 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because all drugs employed did not block either elevation of corticosterone or accumulation of SNARE complexes, the dampening action of the drugs on glutamate release must be downstream of these processes.
Negative_regulation (block) of Positive_regulation (accumulation) of SNARE associated with glutamate
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2797327 Disease Relevance 0.81 Pain Relevance 0.39
We found that all drug treatments employed here did not block either elevation of circulating levels of CORT or accumulation of SNARE complexes in presynaptic membranes, suggesting that the dampening action of drugs on glutamate release must be on pathways located downstream of these processes and/or on alternative pathways.
Negative_regulation (block) of Positive_regulation (accumulation) of SNARE associated with glutamate
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.37 Pain Relevance 0.32

General Comments

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