INT290830

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 4.23
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Napb) vesicle-mediated transport (Napb)
Anatomy Link Frequency
frontal cortex 3
prefrontal 1
Napb (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 396 99.96 Very High Very High Very High
antidepressant 156 99.28 Very High Very High Very High
antagonist 36 97.24 Very High Very High Very High
Pyramidal cell 60 91.92 High High
monoamine 6 85.12 High High
Desipramine 24 80.16 Quite High
fluoxetine 18 76.00 Quite High
excitatory amino acid 6 75.40 Quite High
cytokine 6 44.52 Quite Low
Neurotransmitter 30 43.56 Quite Low
Disease Link Frequency Relevance Heat
Stress 654 99.98 Very High Very High Very High
Urological Neuroanatomy 36 97.56 Very High Very High Very High
Anxiety Disorder 24 75.52 Quite High
Suicidal Behaviour 6 75.52 Quite High
Schizophrenia 6 74.88 Quite High
Disease 24 60.56 Quite High
Shock 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the molecular level, stress induced accumulation of presynaptic SNARE complexes in synaptic membranes (both in vehicle- and drug-treated rats).
Positive_regulation (induced) of Positive_regulation (accumulation) of SNARE associated with stress
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2797327 Disease Relevance 1.25 Pain Relevance 0.58
As observed above for raised CORT levels, these results would suggest that: (i) chronic antidepressant treatments do not block the stress-induced accumulation of SNARE complexes; (ii) the site of action of antidepressants in the modulation of stress-induced glutamate release in P/FC is downstream of SNARE complex formation.


Positive_regulation (induced) of Positive_regulation (accumulation) of SNARE associated with stress, glutamate and antidepressant
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.59 Pain Relevance 0.38
We found that all drug treatments employed here did not block either elevation of circulating levels of CORT or accumulation of SNARE complexes in presynaptic membranes, suggesting that the dampening action of drugs on glutamate release must be on pathways located downstream of these processes and/or on alternative pathways.
Positive_regulation (elevation) of Positive_regulation (accumulation) of SNARE associated with glutamate
3) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.37 Pain Relevance 0.32
Moreover, kindling, a model of epileptogenesis associated with sustained enhanced release of glutamate, induces long-term accumulation of SNARE complexes in rat HPC synaptosomes [26].
Positive_regulation (induces) of Positive_regulation (accumulation) of SNARE associated with glutamate
4) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.64 Pain Relevance 0.15
Here we found that acute footshock (FS)-stress up-regulates depolarization-evoked exocytotic glutamate release in prefrontal/frontal cortex (P/FC) but not HPC, by increasing the circulating levels of CORT, stimulating glucocorticoid receptors (GR) in P/FC, and inducing accumulation of SNARE complexes in presynaptic membranes.
Positive_regulation (inducing) of Positive_regulation (accumulation) of SNARE in frontal cortex associated with stress, glutamate and urological neuroanatomy
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.69 Pain Relevance 0.29
Here we found that acute footshock (FS)-stress up-regulates depolarization-evoked exocytotic glutamate release in prefrontal/frontal cortex (P/FC) but not HPC, by increasing the circulating levels of CORT, stimulating glucocorticoid receptors (GR) in P/FC, and inducing accumulation of SNARE complexes in presynaptic membranes.
Positive_regulation (inducing) of in prefrontal Positive_regulation (accumulation) of SNARE in frontal cortex associated with stress, glutamate and urological neuroanatomy
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.69 Pain Relevance 0.29

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