INT290831

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 7.65
Pain Relevance 3.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Napb) vesicle-mediated transport (Napb)
Anatomy Link Frequency
frontal cortex 2
vesicles 1
prefrontal 1
Napb (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 726 99.76 Very High Very High Very High
antidepressant 286 99.12 Very High Very High Very High
antagonist 66 96.92 Very High Very High Very High
Glutamate receptor 22 96.04 Very High Very High Very High
Pyramidal cell 110 91.92 High High
Neurotransmitter 55 84.96 Quite High
monoamine 11 83.40 Quite High
addiction 11 82.28 Quite High
Desipramine 44 80.16 Quite High
fluoxetine 33 75.68 Quite High
Disease Link Frequency Relevance Heat
Stress 1199 99.98 Very High Very High Very High
Urological Neuroanatomy 66 99.84 Very High Very High Very High
Suicidal Behaviour 11 99.12 Very High Very High Very High
Schizophrenia 11 98.80 Very High Very High Very High
Disease 44 83.28 Quite High
Anxiety Disorder 44 75.20 Quite High
Shock 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the molecular level, stress induced accumulation of presynaptic SNARE complexes in synaptic membranes (both in vehicle- and drug-treated rats).
Positive_regulation (accumulation) of SNARE associated with stress
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2797327 Disease Relevance 1.25 Pain Relevance 0.58
We found that all drug treatments employed here did not block either elevation of circulating levels of CORT or accumulation of SNARE complexes in presynaptic membranes, suggesting that the dampening action of drugs on glutamate release must be on pathways located downstream of these processes and/or on alternative pathways.
Positive_regulation (accumulation) of SNARE associated with glutamate
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.37 Pain Relevance 0.31
Interestingly, SNARE complexes were found to be increased in frontal cortex of suicide schizophrenic and depressed individuals [35].
Positive_regulation (increased) of SNARE in frontal cortex associated with suicidal behaviour, urological neuroanatomy and schizophrenia
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.80 Pain Relevance 0.14
Here we found that acute footshock (FS)-stress up-regulates depolarization-evoked exocytotic glutamate release in prefrontal/frontal cortex (P/FC) but not HPC, by increasing the circulating levels of CORT, stimulating glucocorticoid receptors (GR) in P/FC, and inducing accumulation of SNARE complexes in presynaptic membranes.
Positive_regulation (accumulation) of SNARE in frontal cortex associated with stress, glutamate and urological neuroanatomy
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.69 Pain Relevance 0.28
As observed above for raised CORT levels, these results would suggest that: (i) chronic antidepressant treatments do not block the stress-induced accumulation of SNARE complexes; (ii) the site of action of antidepressants in the modulation of stress-induced glutamate release in P/FC is downstream of SNARE complex formation.


Positive_regulation (accumulation) of SNARE associated with stress, glutamate and antidepressant
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.59 Pain Relevance 0.38
Instead, FS-stress induced rapid and significant changes in the amount of SNARE complexes, in line with the rapid increase of glutamate release (Fig. 4).
Positive_regulation (induced) of SNARE associated with stress and glutamate
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.46 Pain Relevance 0.33
Thus, the data indicate that the effects of stress are two-sided: stress increases glutamate release by increasing the number of SNARE complexes and the probability of release, and also affects the kinetic properties of postsynaptic glutamate receptors.
Positive_regulation (increasing) of SNARE associated with stress, glutamate and glutamate receptor
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.86 Pain Relevance 0.38
Previous evidence has shown that the number of SNARE complexes can be increased by chemical treatment of synaptosomes, suggesting a correlation between the accumulation of complexes and the number of vesicles available for release [25].
Positive_regulation (increased) of SNARE in vesicles
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.52 Pain Relevance 0.18
Moreover, kindling, a model of epileptogenesis associated with sustained enhanced release of glutamate, induces long-term accumulation of SNARE complexes in rat HPC synaptosomes [26].
Positive_regulation (accumulation) of SNARE associated with glutamate
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.64 Pain Relevance 0.15
Because all drugs employed did not block either elevation of corticosterone or accumulation of SNARE complexes, the dampening action of the drugs on glutamate release must be downstream of these processes.
Positive_regulation (accumulation) of SNARE associated with glutamate
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2797327 Disease Relevance 0.79 Pain Relevance 0.38
Here we found that acute footshock (FS)-stress up-regulates depolarization-evoked exocytotic glutamate release in prefrontal/frontal cortex (P/FC) but not HPC, by increasing the circulating levels of CORT, stimulating glucocorticoid receptors (GR) in P/FC, and inducing accumulation of SNARE complexes in presynaptic membranes.
Positive_regulation (accumulation) of SNARE in prefrontal associated with stress, glutamate and urological neuroanatomy
11) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.69 Pain Relevance 0.28

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