INT29084

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.29
First Reported 1987
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.24
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
pars distalis 3
hypothalamus 1
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 13 100.00 Very High Very High Very High
narcan 10 100.00 Very High Very High Very High
antidepressant 40 99.80 Very High Very High Very High
antagonist 22 87.92 High High
depression 42 84.32 Quite High
sSRI 91 77.84 Quite High
Opioid 2 75.00 Quite High
opiate 2 62.88 Quite High
medulla 6 58.04 Quite High
dexamethasone 1 55.12 Quite High
Disease Link Frequency Relevance Heat
Stress 86 94.80 High High
Depression 50 84.32 Quite High
Hypersensitivity 3 67.16 Quite High
Affective Disorder 14 65.84 Quite High
Obesity 4 58.88 Quite High
Targeted Disruption 62 33.84 Quite Low
Neurodegenerative Disease 4 24.32 Low Low
Aggression 18 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Anxiety Disorder 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The apparent flip in control of ACTH release from Crh to Avp that is seen in some repeated stressors in rats (e.g. restraint) has made Avp and the Avpr1b attractive targets for pharmacological intervention in conditions of repeated or chronic stress, although it should be noted that Avp does not play a role in HPA axis responses to all chronic stressors (e.g. chronic morphine injection (Domokos et al. 2008)).
Regulation (control) of Localization (release) of Crh associated with stress and morphine
1) Confidence 0.29 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.80 Pain Relevance 0.12
Antidepressants also can alter the synthesis and release of CRH, thereby normalizing the HPA axis (Brady et al 1991; Torres et al 1998).
Regulation (alter) of Localization (release) of CRH associated with antidepressant
2) Confidence 0.16 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.44 Pain Relevance 0.49
The effects of morphine and naloxone on the secretion in vitro of corticotrophin (ACTH) and and corticotrophin-releasing factor (CRF) by the pars distalis and hypothalamus, respectively, have been studied in the trout.
Regulation (effects) of Localization (secretion) of corticotrophin-releasing factor in pars distalis associated with narcan and morphine
3) Confidence 0.03 Published 1987 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 2822526 Disease Relevance 0 Pain Relevance 0.56
The effects of morphine and naloxone on the secretion in vitro of corticotrophin (ACTH) and and corticotrophin-releasing factor (CRF) by the pars distalis and hypothalamus, respectively, have been studied in the trout.
Regulation (effects) of in hypothalamus Localization (secretion) of corticotrophin-releasing factor in pars distalis associated with narcan and morphine
4) Confidence 0.01 Published 1987 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 2822526 Disease Relevance 0 Pain Relevance 0.56

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox