INT2909

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Context Info
Confidence 0.70
First Reported 1978
Last Reported 2010
Negated 13
Speculated 10
Reported most in Abstract
Documents 334
Total Number 344
Disease Relevance 62.10
Pain Relevance 256.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
brain 27
spinal cord 15
neurons 13
neuronal 11
thalamus 7
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 3778 100.00 Very High Very High Very High
Glutamate 925 100.00 Very High Very High Very High
Dopamine 678 100.00 Very High Very High Very High
GABAergic 370 100.00 Very High Very High Very High
Enkephalin 94 100.00 Very High Very High Very High
GABA receptor 93 100.00 Very High Very High Very High
Pyramidal cell 89 100.00 Very High Very High Very High
qutenza 75 100.00 Very High Very High Very High
Potency 73 100.00 Very High Very High Very High
Dynorphin 52 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 55 100.00 Very High Very High Very High
Ganglion Cysts 241 99.96 Very High Very High Very High
Generalized Anxiety Disorder 106 99.92 Very High Very High Very High
Respiratory Paralysis 16 99.90 Very High Very High Very High
Convulsion 1005 99.80 Very High Very High Very High
Li-fraumeni Syndrome 24 99.74 Very High Very High Very High
Cv Unclassified Under Development 103 99.72 Very High Very High Very High
Decapitation 10 99.56 Very High Very High Very High
Pain 506 99.46 Very High Very High Very High
Stress 176 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously we found postnatal binge-like ethanol exposure using an artificial-rearing method in the rat delayed developmental up-regulation of GABA(A) receptors (GABA(A)Rs) in both medial septum/diagonal band (MS/DB) and cerebellar Purkinje neurons.
Positive_regulation (up-regulation) of GABA in band associated with gaba
1) Confidence 0.70 Published 2001 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 11557091 Disease Relevance 0 Pain Relevance 0.30
Previously we found postnatal binge-like ethanol exposure using an artificial-rearing method in the rat delayed developmental up-regulation of GABA(A) receptors (GABA(A)Rs) in both medial septum/diagonal band (MS/DB) and cerebellar Purkinje neurons.
Positive_regulation (up-regulation) of GABA in band associated with gaba
2) Confidence 0.70 Published 2001 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 11557091 Disease Relevance 0 Pain Relevance 0.29
Both lithium and valproic acid significantly increased GABA CSF levels in normonatremic and hyponatremic animals.
Positive_regulation (increased) of GABA CSF associated with gaba
3) Confidence 0.69 Published 1998 Journal Gen. Pharmacol. Section Abstract Doc Link 9522182 Disease Relevance 0.28 Pain Relevance 0.26
The effect of GABA on ME release may be mediated by an atypical GABA receptor which is activated by baclofen.
Positive_regulation (activated) of GABA associated with gaba, gaba receptor and enkephalin
4) Confidence 0.69 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6266839 Disease Relevance 0 Pain Relevance 1.06
Activation of presynaptic GABA(B) receptors attenuates excitatory or inhibitory synaptic transmission.
Positive_regulation (Activation) of GABA associated with gaba
5) Confidence 0.68 Published 1998 Journal Neuroscience Section Abstract Doc Link 9692755 Disease Relevance 0.16 Pain Relevance 0.54
The findings demonstrate that drug-induced increases in GABA(B) receptor function can occur independently of any change in GABA(B) receptor subunit expression and are consistent with the notion that GABA(B) receptor subunits have multiple functions, only one of which is dimerization to form GABA(B) receptors.
Positive_regulation (increases) of GABA associated with gaba
6) Confidence 0.68 Published 2006 Journal Brain Res. Section Abstract Doc Link 16368079 Disease Relevance 0.39 Pain Relevance 1.52
Thus, tiagabine could inhibit or disinhibit globus pallidus neurons by increasing the activation of the GABA(A) receptors and presynaptic GABA(B) receptors, respectively.
Positive_regulation (activation) of GABA in neurons associated with gaba
7) Confidence 0.66 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12879169 Disease Relevance 0 Pain Relevance 0.58
Thus, tiagabine could inhibit or disinhibit globus pallidus neurons by increasing the activation of the GABA(A) receptors and presynaptic GABA(B) receptors, respectively.
Positive_regulation (activation) of GABA in neurons associated with gaba
8) Confidence 0.66 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12879169 Disease Relevance 0 Pain Relevance 0.59
Following AOAA, maximum increases in synaptosomal GABA levels of brain regions were observed 6 hr after administration.
Positive_regulation (increases) of GABA in brain associated with gaba
9) Confidence 0.61 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3924047 Disease Relevance 0.32 Pain Relevance 0.45
A significant increase in GABA levels was also detected during acquisition but only in the mPFC.
Positive_regulation (increase) of GABA associated with gaba
10) Confidence 0.60 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18466328 Disease Relevance 0 Pain Relevance 0.83
The ATP-mediated fast current of rat dorsal root ganglion neurons is a novel effector for GABA(B) receptor activation.
Positive_regulation (activation) of GABA in neurons associated with ganglion cysts, gaba and root ganglion neuron
11) Confidence 0.59 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 12581826 Disease Relevance 0.55 Pain Relevance 1.05
The second is likely to arise from axon collaterals of SNr neurons themselves and is facilitated by an increase in firing via postsynaptic, somatodendritic 5-HT2C receptor activation, but it is depressed by GABA(B) receptor activation.
Positive_regulation (activation) of GABA in neurons associated with gaba
12) Confidence 0.51 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8922413 Disease Relevance 0.06 Pain Relevance 0.72
Barbiturate activation and modulation of GABA(A) receptors in neocortex.
Positive_regulation (activation) of GABA in neocortex associated with gaba
13) Confidence 0.50 Published 2007 Journal Neuropharmacology Section Title Doc Link 17289092 Disease Relevance 0.17 Pain Relevance 0.29
At higher concentrations, pentobarbital and amobarbital shunted firing by increasing input conductance through agonism at GABA(A) receptors.
Positive_regulation (increasing) of GABA associated with gaba
14) Confidence 0.50 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17289092 Disease Relevance 0.17 Pain Relevance 0.39
It has also been reported that positive modulation of GABA(A) receptors in the rat spinal cord can produce antinociception in vivo.
Positive_regulation (modulation) of GABA in spinal cord associated with antinociception, gaba and spinal cord
15) Confidence 0.50 Published 2000 Journal Pain Section Abstract Doc Link 11098097 Disease Relevance 0 Pain Relevance 0.59
We conclude that thiocolchicoside may interact with a subpopulation of GABA(A) receptors having low-affinity binding sites for GABA.
Positive_regulation (subpopulation) of GABA associated with gaba
16) Confidence 0.50 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11406196 Disease Relevance 0 Pain Relevance 0.41
Hypothalamic superfusion with a potassium-rich (50 or 90 mmol/l) artificial cerebrospinal fluid led to a concentration-dependent increase in the GABA release.
Positive_regulation (increase) of GABA in cerebrospinal fluid associated with gaba
17) Confidence 0.50 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8510767 Disease Relevance 0.31 Pain Relevance 0.52
More importantly, the observation that CGP 35348 enhanced excitatory synaptic currents implies a removal of tonic activation of presynaptic GABA(B) receptors by endogenously released GABA (disinhibition), supporting the hypothesis that these receptors may have a physiological role in regulating the input and output ratio in a subset of rostral ventrolateral medulla neurons in vivo.
Positive_regulation (activation) of GABA in medulla associated with rostral ventrolateral medulla and gaba
18) Confidence 0.49 Published 1998 Journal Neuroscience Section Abstract Doc Link 9692755 Disease Relevance 0.15 Pain Relevance 0.53
Activation of postsynaptic GABA(B) receptors induces an outward K+ current which is barium-sensitive, Ca2+-independent and may be coupled to a pertussis-sensitive G-protein.
Positive_regulation (Activation) of GABA associated with gaba and bordatella infection
19) Confidence 0.49 Published 1998 Journal Neuroscience Section Abstract Doc Link 9692755 Disease Relevance 0.17 Pain Relevance 0.58
In the present study, the whole-cell mode of the patch-clamp technique was applied to neurons of the CA1 pyramidal layer of rat hippocampal slices to investigate the effects of the organophosphate (OP) sarin on field stimulation-evoked and on tetrodotoxin (TTX)-insensitive postsynaptic currents (PSCs) mediated by activation of type A gamma-aminobutyric acid (GABA) receptors or AMPA-type glutamate receptors.
Positive_regulation (activation) of GABA in pyramidal layer associated with tetrodotoxin, gaba and glutamate receptor
20) Confidence 0.49 Published 1999 Journal Neurotoxicology Section Abstract Doc Link 10693968 Disease Relevance 0 Pain Relevance 0.50

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