INT290904

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Shh, Prkcg) plasma membrane (Shh, Prkcg) anatomical structure formation involved in morphogenesis (Shh)
embryo development (Shh) anatomical structure development (Shh) peptidase activity (Shh)
Anatomy Link Frequency
MSCs 1
Shh (Rattus norvegicus)
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 2 40.00 Quite Low
ischemia 2 13.72 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Neuronal nitric oxide synthase 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 63.84 Quite High
Injury 4 20.20 Low Low
Cancer 2 15.52 Low Low
Cv Unclassified Under Development 2 13.72 Low Low
Myocardial Infarction 12 5.00 Very Low Very Low Very Low
Infarction 8 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Fibrosis 2 5.00 Very Low Very Low Very Low
Hemangioma 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that Shh transgene over expression in MSCs initiated PKC signaling which was characterized by the activation of PKM, a catalytic fragment of PKC.
Shh transgene Positive_regulation (initiated) of PKC in MSCs
1) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.06 Pain Relevance 0
Shh-induced upregulation of netrin-1 and iNOS was PKC dependent.
Shh Positive_regulation (upregulation) of PKC
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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