INT290912

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.14
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pkm2) plasma membrane (Pkm2) nucleus (Pkm2)
cytoplasm (Pkm2)
Anatomy Link Frequency
MSCs 1
Pkm2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 4 70.32 Quite High
anesthesia 4 44.48 Quite Low
metalloproteinase 4 40.12 Quite Low
ischemia 4 10.00 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
Neuronal nitric oxide synthase 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 4 84.56 Quite High
Apoptosis 4 60.12 Quite High
Injury 8 16.48 Low Low
Cancer 4 11.80 Low Low
Cv Unclassified Under Development 4 10.00 Low Low
Myocardial Infarction 24 5.00 Very Low Very Low Very Low
Infarction 16 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Fibrosis 4 5.00 Very Low Very Low Very Low
Hemangioma 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that Shh transgene over expression in MSCs initiated PKC signaling which was characterized by the activation of PKM, a catalytic fragment of PKC.
Positive_regulation (activation) of PKM in MSCs
1) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.06 Pain Relevance 0
We further observed that PKM was upregulated in ShhMSCs and was sensitive to cyclopamine and chel pretreatment of the cells.


Positive_regulation (upregulated) of PKM
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0
Our results showed that netrin-1 expression increased significantly in ShhMSCs both at the protein and RNA levels in PKC (PKM) dependent fashion.
Positive_regulation (increased) of PKM
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.08 Pain Relevance 0.04
We also found that Shh overexpression also induced panPKC fragment PKM (45 kd; a proteolytic subunit of PKC) in ShhMSCs which was completely abolished by pretreatment of the cells with 2.5 µM chel or 1 µM cyclopamine (Figure 3E).
Positive_regulation (induced) of PKM
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox