INT290915

Context Info Confidence 0.15 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0.03

Golgi apparatus (Smo) plasma membrane (Smo) cilium (Smo) molecular_function (Smo) cytoplasm (Smo) signal transducer activity (Smo)

Smo (Rattus norvegicus)

Pain Link Frequency Relevance Heat fibrosis 1 61.52 cytokine 3 42.00 Central nervous system 1 5.00 Neuronal nitric oxide synthase 1 5.00 anesthesia 1 5.00 Inflammation 1 5.00 ischemia 1 5.00 Inflammatory response 1 5.00 metalloproteinase 1 5.00

Disease Link Frequency Relevance Heat Fibrosis 1 61.52 Myocardial Infarction 6 46.60 Infarction 4 5.00 Injury 2 5.00 INFLAMMATION 2 5.00 Hemangioma 1 5.00 Apoptosis 1 5.00 Death 1 5.00 Cv Unclassified Under Development 1 5.00 Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Hedgehog signaling involves binding of hedgehog with its ptch-1 receptor which in turn releases its inhibitory effect on Smoothened (smo).

smo Binding (binding) of

1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

This test has worked.