INT290916

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Angpt1) signal transduction (Angpt1) extracellular space (Angpt1)
extracellular region (Angpt1) plasma membrane (Angpt1) molecular_function (Angpt1)
Anatomy Link Frequency
myocardium 1
heart 1
Angpt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 5 73.36 Quite High
Percutaneous transluminal coronary angioplasty 1 12.72 Low Low
fibrosis 16 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Neuronal nitric oxide synthase 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 75 87.92 High High
Diabetes Mellitus 93 87.80 High High
Injury 2 79.84 Quite High
Cancer 1 75.16 Quite High
Cv Unclassified Under Development 4 73.36 Quite High
Apoptosis 4 63.04 Quite High
Ventricular Remodeling 10 50.00 Quite Low
Coronary Artery Disease 5 14.92 Low Low
Stress 3 6.96 Low Low
Fibrosis 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the authors demonstrated the synergistic effect of coadministration of VEGF and Ang-1 in the ischemic rat myocardium (18).
Regulation (effect) of Ang-1 in myocardium
1) Confidence 0.31 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.72 Pain Relevance 0
Interestingly, activation of Shh signaling caused upregulation of pro-angiogenic growth factors including vascular endothelial growth factor (VEGF) and angiopoietin-1 which resulted in an increased angiogenic response and globally improved the heart function.
Regulation (upregulation) of angiopoietin-1 in heart
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.29 Pain Relevance 0.04

General Comments

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