INT290922

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) aging (Mmp9)
extracellular region (Mmp9) proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9)
Anatomy Link Frequency
cartilage 2
extracellular matrix 2
Mmp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 42 99.92 Very High Very High Very High
Pain 34 92.68 High High
Inflammation 2 72.12 Quite High
Osteoarthritis 33 68.96 Quite High
Neuronal nitric oxide synthase 1 61.72 Quite High
Central nervous system 1 45.28 Quite Low
cytokine 3 43.48 Quite Low
fibrosis 1 22.48 Low Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 33 92.68 High High
Disease 3 86.88 High High
INFLAMMATION 3 72.12 Quite High
Osteoarthritis 33 68.96 Quite High
Synovitis 2 45.88 Quite Low
Fibrosis 1 22.48 Low Low
Increased Venous Pressure Under Development 1 17.20 Low Low
Osteophyte 7 5.00 Very Low Very Low Very Low
Myocardial Infarction 6 5.00 Very Low Very Low Very Low
Infarction 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduction in chondropathy scores is likely due to a direct effect of the MMPi on proteinases, such as collagenase 3 or MMP9, that can degrade cartilage matrix proteins.
Spec (likely) Regulation (effect) of Protein_catabolism (degrade) of MMP9 in cartilage
1) Confidence 0.28 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2853084 Disease Relevance 0.73 Pain Relevance 0.64
More recent studies have shown that NO generated from iNOS activity modulates the expression of matrix metalloproteinase-9 (MMP-9), an enzyme responsible for degradation of extracellular matrix, which significantly influenced cell migration [21].
Regulation (responsible) of Protein_catabolism (degradation) of MMP-9 in extracellular matrix associated with metalloproteinase
2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.06 Pain Relevance 0.11

General Comments

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